Games like Wyrd Gun
Games like Wyrd Gun include Risk of Rain 2, The Binding of Isaac, Noita, Gunfire Reborn, and Magicraft. We matched them by the tags players give Wyrd Gun on Steam (Action Roguelike, Looter Shooter, Procedural Generation, Difficult, and Roguelite): closest matches first, and among equally close ones the better-known games.

Risk of Rain 2
Shared: Action Roguelike · Looter Shooter · Roguelite

The Binding of Isaac
Shared: Action Roguelike · Difficult · Procedural Generation

Noita
Shared: Difficult · Roguelike · Action Roguelike

Gunfire Reborn
Shared: Roguelite · Looter Shooter · Action Roguelike

Magicraft
Shared: Action Roguelike · Looter Shooter · Roguelite

Roboquest
Shared: Action Roguelike · Roguelite · Looter Shooter

SULFUR
Shared: Action Roguelike · Gun Customization · Roguelite

Deadzone: Rogue
Shared: Looter Shooter · Roguelite · Roguelike

The Binding of Isaac: Rebirth
Shared: Action Roguelike · Difficult · Roguelike

Hades
Shared: Action Roguelike · Roguelite · Roguelike

Ziggurat
Shared: Action Roguelike · Roguelite · Procedural Generation

Megabonk
Shared: Action Roguelike · Roguelite · Roguelike

Dead Cells
Shared: Action Roguelike · Roguelite · Roguelike

Crab Champions
Shared: Action Roguelike · Looter Shooter · Roguelike

Nuclear Throne
Shared: Action Roguelike · Difficult · Roguelike

FTL: Faster Than Light
Shared: Difficult · Roguelike · Perma Death

Enter the Gungeon
Shared: Action Roguelike · Difficult · Roguelike

Borderlands 2
Shared: Looter Shooter · Loot · Shooter

Caveblazers
Shared: Action Roguelike · Roguelite · Procedural Generation

Neon Abyss
Shared: Procedural Generation · Loot · Roguelike

Deep Rock Galactic
Shared: Procedural Generation · Shooter · Loot

One Step From Eden
Shared: Action Roguelike · Roguelite · Difficult

Vagante
Shared: Action Roguelike · Difficult · Roguelite

Spelunky
Shared: Action Roguelike · Difficult · Procedural Generation