Games like Witchtower: Spell Siege
Games like Witchtower: Spell Siege include Vampire Survivors, Wizard of Legend, Skul: The Hero Slayer, The Binding of Isaac: Rebirth, and Sephiria. We matched them by the tags players give Witchtower: Spell Siege on Steam (Tower Defense, Action Roguelike, Roguelite, Strategy, and Magic): closest matches first, and among equally close ones the better-known games.

Vampire Survivors
Shared: Action Roguelike · Roguelite · Pixel Graphics

Wizard of Legend
Shared: Action Roguelike · Magic · Local Co-Op

Skul: The Hero Slayer
Shared: Action Roguelike · Action · Roguelite

The Binding of Isaac: Rebirth
Shared: Action Roguelike · Pixel Graphics · Indie

Sephiria
Shared: Action Roguelike · Roguelite · Co-op

Orcs Must Die! Deathtrap
Shared: Tower Defense · Roguelite · Strategy

Necrosmith
Shared: Action Roguelike · Tower Defense · Roguelite

Halls of Torment
Shared: Action Roguelike · Roguelite · Action

Streets of Rogue
Shared: Action Roguelike · Roguelite · Action

Hades
Shared: Action Roguelike · Roguelite · Action

Bloons TD 6
Shared: Tower Defense · Strategy · Co-op

Enter the Gungeon
Shared: Action Roguelike · Pixel Graphics · Local Co-Op

Death Must Die
Shared: Action Roguelike · Roguelite · Action

Cult of the Lamb
Shared: Action Roguelike · Roguelite · Strategy

Nuclear Throne
Shared: Action Roguelike · Roguelite · Action

Dead Cells
Shared: Action Roguelike · Roguelite · 2D

Risk of Rain (2013)
Shared: Action Roguelike · Action · Pixel Graphics

Kingdom Rush Frontiers - Tower Defense
Shared: Tower Defense · Strategy · 2D

Ship of Fools
Shared: Action Roguelike · Roguelite · Local Co-Op

Risk of Rain 2
Shared: Action Roguelike · Roguelite · Co-op

Shape of Dreams
Shared: Action Roguelike · Roguelite · Co-op

Kingdom Rush - Tower Defense
Shared: Tower Defense · Strategy · 2D

Kingdom Rush 5: Alliance TD
Shared: Tower Defense · Strategy · 2D

GemCraft - Chasing Shadows
Shared: Tower Defense · Strategy · Action