Games like We Are the Universe
Games like We Are the Universe include Bloons TD 6, Defense Grid: The Awakening, Creeper World 3: Arc Eternal, Plants vs. Zombies GOTY Edition, and FTL: Faster Than Light. We matched them by the tags players give We Are the Universe on Steam (Strategy, Tower Defense, Sci-fi, 3D, and Singleplayer): closest matches first, and among equally close ones the better-known games.

Bloons TD 6
Shared: Strategy · Tower Defense · Singleplayer

Defense Grid: The Awakening
Shared: Strategy · Tower Defense · Sci-fi

Creeper World 3: Arc Eternal
Shared: Strategy · Tower Defense · Sci-fi

Plants vs. Zombies GOTY Edition
Shared: Tower Defense · Strategy · Singleplayer

FTL: Faster Than Light
Shared: Strategy · Sci-fi · Singleplayer

Sanctum 2
Shared: Tower Defense · Strategy · Sci-fi

X-Morph: Defense
Shared: Strategy · Tower Defense · Sci-fi

Infested Planet
Shared: Strategy · Tower Defense · Singleplayer

Outpost: Infinity Siege
Shared: Tower Defense · 3D · Singleplayer

Emberward
Shared: Tower Defense · Strategy · 3D

Space Run
Shared: Strategy · Tower Defense · Sci-fi

Dungeon of the ENDLESS™
Shared: Strategy · Tower Defense · Sci-fi

Taur
Shared: Strategy · Tower Defense · Sci-fi

Cosmoteer: Starship Architect & Commander
Shared: Sci-fi · Singleplayer · Strategy

Kingdom Rush 5: Alliance TD
Shared: Strategy · Tower Defense · Singleplayer

Kingdom Rush - Tower Defense
Shared: Strategy · Tower Defense · Singleplayer

Anomaly Warzone Earth
Shared: Strategy · Tower Defense · Sci-fi

Thronefall
Shared: Strategy · Tower Defense · 3D

Rogue Tower
Shared: Strategy · Tower Defense · 3D

GemCraft - Chasing Shadows
Shared: Strategy · Tower Defense · Singleplayer

Buckshot Roulette
Shared: Strategy · Singleplayer · Indie

Kingdom Rush Frontiers - Tower Defense
Shared: Strategy · Tower Defense · Singleplayer

Orcs Must Die!
Shared: Tower Defense · Strategy · Indie

Kingdom Two Crowns
Shared: Tower Defense · Strategy · Singleplayer