Games like Up's and Wipes
Games like Up's and Wipes include Stardew Valley, DAVE THE DIVER, Vampire Survivors, Timberman, and UNO. We matched them by the tags players give Up's and Wipes on Steam (Casual, 2D, Pixel Graphics, Old School, and Relaxing): closest matches first, and among equally close ones the better-known games.

Stardew Valley
Shared: Pixel Graphics · Relaxing · Multiplayer

DAVE THE DIVER
Shared: Casual · Pixel Graphics · Relaxing

Vampire Survivors
Shared: Pixel Graphics · 2D · Casual

Timberman
Shared: Casual · Pixel Graphics · 2D

UNO
Shared: Casual · Tabletop · Multiplayer

Balatro
Shared: Pixel Graphics · Card Game · Singleplayer

Unpacking
Shared: Casual · Relaxing · Pixel Graphics

Terraria
Shared: 2D · Pixel Graphics · Multiplayer

Bloons TD 6
Shared: Casual · Singleplayer · Multiplayer

Draw & Guess
Shared: Casual · Multiplayer · 2D

DJMAX RESPECT V
Shared: Casual · 2D · Multiplayer

Ballionaire
Shared: 2D · Casual · Singleplayer

Zup! S
Shared: Casual · 2D · Relaxing

Peggle Deluxe
Shared: Casual · 2D · Singleplayer

PowerWash Simulator
Shared: Casual · Relaxing · Multiplayer

Potion Craft: Alchemist Simulator
Shared: Relaxing · Singleplayer · 2D

Koi-Koi Japan [Hanafuda playing cards]
Shared: Casual · Card Game · 2D

Wingspan
Shared: Relaxing · Casual · Card Game

The Escapists 2
Shared: Pixel Graphics · 2D · Multiplayer

House Flipper
Shared: Casual · Singleplayer · Relaxing

Proverbs
Shared: Casual · 2D · Relaxing

Sun Haven
Shared: Pixel Graphics · Multiplayer · Relaxing

Shelldiver
Shared: Casual · 2D · Relaxing

Purple Place - Classic Games
Shared: Casual · Old School · 2D