Games like Up, Little One
Games like Up, Little One include Celeste, Hollow Knight, Geometry Dash, Super Meat Boy, and Hollow Knight: Silksong. We matched them by the tags players give Up, Little One on Steam (Precision Platformer, Action, Difficult, Platformer, and 2D): closest matches first, and among equally close ones the better-known games.

Celeste
Shared: Precision Platformer · Difficult · Platformer

Hollow Knight
Shared: Platformer · Difficult · 2D

Geometry Dash
Shared: Difficult · Precision Platformer · 2D

Super Meat Boy
Shared: Precision Platformer · Difficult · Platformer

Hollow Knight: Silksong
Shared: Difficult · 2D · Platformer

Jump King
Shared: Precision Platformer · Difficult · Platformer

Rain World
Shared: Difficult · Atmospheric · Platformer

Nine Sols
Shared: Difficult · Action · Platformer

The End Is Nigh
Shared: Precision Platformer · Platformer · Difficult

Ori and the Will of the Wisps
Shared: Platformer · Action · Atmospheric

Skul: The Hero Slayer
Shared: Action · 2D · Indie

Cuphead
Shared: Difficult · Platformer · 2D

Super Meat Boy Forever
Shared: Action · Difficult · Precision Platformer

LIMBO
Shared: Platformer · Indie · 2D

VVVVVV
Shared: Precision Platformer · Platformer · Difficult

SANABI
Shared: Action · 2D · Platformer

Getting Over It with Bennett Foddy
Shared: Difficult · Platformer · Physics

Downwell
Shared: Precision Platformer · Platformer · Action

Salt and Sanctuary
Shared: Difficult · 2D · Action

Wings of Vi
Shared: Precision Platformer · Difficult · Platformer

BEEP
Shared: Platformer · 2D · Action

Electronic Super Joy
Shared: Platformer · Difficult · Action

A Difficult Game About Climbing
Shared: Difficult · Precision Platformer · Platformer

Katana ZERO
Shared: Action · Platformer · 2D