Games like Twilight Canyon
Games like Twilight Canyon include Hades, Hades II, Megabonk, Vampire Survivors, and Skul: The Hero Slayer. We matched them by the tags players give Twilight Canyon on Steam (Action Roguelike, Perma Death, Indie, Roguelike, and Roguelite): closest matches first, and among equally close ones the better-known games.

Hades
Shared: Action Roguelike · Indie · Roguelite

Hades II
Shared: Roguelike · Action Roguelike · Roguelite

Megabonk
Shared: Action Roguelike · Roguelike · Indie

Vampire Survivors
Shared: Action Roguelike · Roguelite · Indie

Skul: The Hero Slayer
Shared: Action Roguelike · Indie · Roguelike

Realm of the Mad God Exalt
Shared: Roguelike · Perma Death · Action Roguelike

Risk of Rain (2013)
Shared: Action Roguelike · Indie · Roguelike

Halls of Torment
Shared: Action Roguelike · Roguelite · Roguelike

Risk of Rain 2
Shared: Action Roguelike · Roguelike · Roguelite

Soulstone Survivors
Shared: Action Roguelike · Roguelite · Roguelike

The Binding of Isaac: Rebirth
Shared: Action Roguelike · Indie · Roguelike

The Binding of Isaac
Shared: Action Roguelike · Indie · Roguelike

Rogue Legacy
Shared: Action Roguelike · Indie · Roguelike

Gunfire Reborn
Shared: Roguelike · Roguelite · Indie

Death Must Die
Shared: Action Roguelike · Roguelite · Roguelike

FTL: Faster Than Light
Shared: Roguelike · Indie · Strategy

Touhou Dystopian
Shared: Action Roguelike · Roguelite · Action

Brotato
Shared: Action Roguelike · Roguelike · Roguelite

Yet Another Zombie Survivors
Shared: Action Roguelike · Indie · Roguelite

Streets of Rogue
Shared: Action Roguelike · Roguelite · Roguelike

Everything is Crab: The Animal Evolution Roguelite
Shared: Action Roguelike · Roguelite · Strategy

Nuclear Throne
Shared: Action Roguelike · Roguelike · Indie

Nordic Ashes: Survivors of Ragnarok
Shared: Action Roguelike · Roguelite · Roguelike

Jotunnslayer: Hordes of Hel
Shared: Action Roguelike · Roguelite · Roguelike