Games like Twenty One
Games like Twenty One include Across the Obelisk, Balatro, Overdungeon, The Legend of Bum-Bo, and Reigns. We matched them by the tags players give Twenty One on Steam (Indie, Casual, Strategy, Adventure, and Card Game): closest matches first, and among equally close ones the better-known games.

Across the Obelisk
Shared: Casual · Adventure · Card Game

Balatro
Shared: Card Game · Strategy · Indie

Overdungeon
Shared: Indie · Strategy · Casual

The Legend of Bum-Bo
Shared: Indie · Strategy · Adventure

Reigns
Shared: Indie · Card Game · Adventure

Home Behind
Shared: Indie · Adventure · Casual

Plebby Quest: The Crusades
Shared: Casual · Indie · Strategy

Game Dev Tycoon
Shared: Indie · Strategy · Casual

Plague Inc: Evolved
Shared: Strategy · Indie · Casual

Chrono Ark
Shared: Indie · Strategy · Adventure

Florence
Shared: Indie · Casual · Adventure

Achievement Clicker
Shared: Casual · Indie · Strategy

The Scroll of Taiwu : Beyond The Dome
Shared: Indie · Strategy · Adventure

Rock 'N' Roll Defense
Shared: Casual · Strategy · Indie

Caster
Shared: Indie · Adventure · Casual

Faeria
Shared: Strategy · Indie · Card Game

Mini Motorways
Shared: Strategy · Casual · Indie

Slay the Spire 2
Shared: Card Game · Strategy · Indie

Pikuniku
Shared: Indie · Casual · Adventure

Run!ZombieFood!
Shared: Casual · Strategy · Indie

100% Orange Juice
Shared: Strategy · Indie · Card Game

Sultan's Game
Shared: Strategy · Card Game · Adventure

Moncage
Shared: Casual · Indie · Adventure

Idle Champions of the Forgotten Realms
Shared: Strategy · Adventure · Indie