Games like Trackline Express
Games like Trackline Express include The Binding of Isaac, Deadly Days, The Binding of Isaac: Rebirth, Bloons TD 5, and Megabonk. We matched them by the tags players give Trackline Express on Steam (Action Roguelike, Trains, Casual, Survival, and Difficult): closest matches first, and among equally close ones the better-known games.

The Binding of Isaac
Shared: Action Roguelike · Difficult · Indie

Deadly Days
Shared: Action Roguelike · Casual · Indie

The Binding of Isaac: Rebirth
Shared: Action Roguelike · Difficult · Indie

Bloons TD 5
Shared: Casual · Strategy · Family Friendly

Megabonk
Shared: Action Roguelike · Survival · Indie

Skul: The Hero Slayer
Shared: Action Roguelike · Indie · Action

Witch It
Shared: Casual · Indie · Survival

Don't Starve Together
Shared: Survival · Difficult · Indie

Bloons TD 6
Shared: Strategy · Casual · Family Friendly

Town of Salem
Shared: Strategy · Casual · Indie

20 Minutes Till Dawn
Shared: Action Roguelike · Survival · Casual

Hades
Shared: Action Roguelike · Indie · Action

Unrailed 2: Back on Track
Shared: Trains · Action Roguelike · Survival

Plants vs. Zombies GOTY Edition
Shared: Casual · Strategy · Family Friendly

Vampire Survivors
Shared: Action Roguelike · Casual · Indie

Unrailed!
Shared: Casual · Trains · Indie

Geometry Dash
Shared: Difficult · Indie · Side Scroller

Risk of Rain 2
Shared: Action Roguelike · Action · Difficult

Home Behind
Shared: Survival · Casual · Indie

Octogeddon
Shared: Action Roguelike · Casual · Indie

The Escapists
Shared: Strategy · Difficult · Survival

Passpartout: The Starving Artist
Shared: Casual · Indie · Funny

Factorio
Shared: Survival · Strategy · Casual

Risk of Rain (2013)
Shared: Action Roguelike · Indie · Difficult