Games like Tower Tactics: Astral Siege
Games like Tower Tactics: Astral Siege include Slay the Spire, Balatro, Slay the Spire 2, Tower Tactics: Liberation, and Dicey Dungeons. We matched them by the tags players give Tower Tactics: Astral Siege on Steam (Roguelike Deckbuilder, Tower Defense, Strategy, Card Battler, and Card Game): closest matches first, and among equally close ones the better-known games.

Slay the Spire
Shared: Roguelike Deckbuilder · Card Battler · Card Game

Balatro
Shared: Roguelike Deckbuilder · Card Game · Roguelike

Slay the Spire 2
Shared: Card Game · Roguelike Deckbuilder · Roguelike

Tower Tactics: Liberation
Shared: Roguelike Deckbuilder · Tower Defense · Card Battler

Dicey Dungeons
Shared: Roguelike Deckbuilder · Card Battler · Deckbuilding

9 Kings
Shared: Strategy · Roguelike Deckbuilder · Card Game

Dungeons & Degenerate Gamblers
Shared: Roguelike Deckbuilder · Strategy · Roguelike

Vampire Crawlers: The Turbo Wildcard from Vampire Survivors
Shared: Card Battler · Strategy · Roguelike

Inscryption
Shared: Card Battler · Card Game · Deckbuilding

Die in the Dungeon
Shared: Strategy · Roguelike Deckbuilder · Roguelike

Wildfrost
Shared: Roguelike Deckbuilder · Card Battler · Card Game

DICEOMANCER
Shared: Strategy · Roguelike Deckbuilder · Card Battler

Heretic's Fork
Shared: Tower Defense · Roguelike Deckbuilder · Strategy

Ratropolis
Shared: Card Battler · Strategy · Deckbuilding

Monster Train
Shared: Card Battler · Card Game · Deckbuilding

Cubic Cosmos
Shared: Roguelike Deckbuilder · Card Battler · Strategy

RACCOIN: Coin Pusher Roguelike
Shared: Strategy · Roguelike Deckbuilder · Roguelike

Super Fantasy Kingdom
Shared: Strategy · Roguelike · Roguelike Deckbuilder

FTL: Faster Than Light
Shared: Strategy · Roguelike · Singleplayer

Luck be a Landlord
Shared: Roguelike Deckbuilder · Strategy · Deckbuilding

Vault of the Void
Shared: Roguelike Deckbuilder · Strategy · Card Battler

Stacklands
Shared: Card Game · Card Battler · Strategy

Griftlands
Shared: Card Battler · Deckbuilding · Roguelite

Roguebook
Shared: Card Game · Strategy · Deckbuilding