Games like Total Synthesis
Games like Total Synthesis include Balatro, Slay the Spire 2, Braid, Inscryption, and Zup! S. We matched them by the tags players give Total Synthesis on Steam (2D Platformer, Strategy, Puzzle Platformer, Puzzle, and Education): closest matches first, and among equally close ones the better-known games.

Balatro
Shared: Strategy · Card Game · Roguelike

Slay the Spire 2
Shared: Strategy · Card Game · Roguelike

Braid
Shared: 2D Platformer · Puzzle Platformer · Puzzle

Inscryption
Shared: Card Game · Puzzle · Strategy

Zup! S
Shared: Puzzle · Casual · 2D

Zup!
Shared: Puzzle · Casual · Puzzle Platformer

Slay the Spire
Shared: Strategy · Card Game · Roguelike

Zup! 3
Shared: Puzzle · Casual · Puzzle Platformer

Öoo
Shared: 2D Platformer · Puzzle Platformer · Puzzle

Webbed
Shared: 2D Platformer · Puzzle Platformer · 2D

Mini Metro
Shared: Strategy · Puzzle · Casual

Mini Motorways
Shared: Strategy · Casual · Puzzle

RACCOIN: Coin Pusher Roguelike
Shared: Strategy · Roguelike · Casual

9 Kings
Shared: Strategy · Card Game · Roguelike

Zup! F
Shared: Puzzle · Casual · Puzzle Platformer

Demonic Mahjong
Shared: Strategy · Card Game · Casual

Trine 2: Complete Story
Shared: Puzzle Platformer · 2D Platformer · Puzzle

Laughing to Die
Shared: 2D Platformer · Puzzle · Casual

Zup! 2
Shared: Puzzle · Casual · Puzzle Platformer

Dorfromantik
Shared: Puzzle · Strategy · Casual

Zup! Z
Shared: Puzzle · Casual · Puzzle Platformer

Zup! X
Shared: Puzzle · Casual · Puzzle Platformer

Planet of Lana
Shared: Puzzle Platformer · 2D Platformer · Puzzle

Zup! 7
Shared: Puzzle · Casual · Puzzle Platformer