Games like Total City Defence
Games like Total City Defence include Skul: The Hero Slayer, BlazBlue Entropy Effect, Vampire Survivors, HighFleet, and Plague Inc: Evolved. We matched them by the tags players give Total City Defence on Steam (Action Roguelike, Strategy, Exploration, Action, and Outbreak Sim): closest matches first, and among equally close ones the better-known games.

Skul: The Hero Slayer
Shared: Action Roguelike · Action · 2D

BlazBlue Entropy Effect
Shared: Action Roguelike · Action · 2D

Vampire Survivors
Shared: Action Roguelike · 2D · Pixel Graphics

HighFleet
Shared: Strategy · Action Roguelike · Post-apocalyptic

Plague Inc: Evolved
Shared: Strategy · Outbreak Sim · Indie

60 Seconds! Reatomized
Shared: Strategy · Exploration · 2D

Cult of the Lamb
Shared: Action Roguelike · Colony Sim · Strategy

Rain World
Shared: Exploration · 2D · Pixel Graphics

Nordic Ashes: Survivors of Ragnarok
Shared: Action Roguelike · Exploration · Strategy

The Binding of Isaac: Rebirth
Shared: Action Roguelike · Pixel Graphics · Indie

Infection Free Zone
Shared: Strategy · Post-apocalyptic · Outbreak Sim

Terraria
Shared: 2D · Exploration · Pixel Graphics

Everything is Crab: The Animal Evolution Roguelite
Shared: Action Roguelike · Strategy · Action

Rogue Legacy
Shared: Action Roguelike · Action · 2D

The Escapists
Shared: Strategy · Action · Pixel Graphics

Dome Keeper
Shared: Action · Post-apocalyptic · Sci-fi

Nuclear Throne
Shared: Action Roguelike · Action · Pixel Graphics

Until We Die
Shared: Strategy · Action · Pixel Graphics

RimWorld
Shared: Strategy · Colony Sim · Sci-fi

Death Must Die
Shared: Action Roguelike · Action · Pixel Graphics

Oxygen Not Included
Shared: Colony Sim · Strategy · 2D

Fallout 4
Shared: Exploration · Post-apocalyptic · Action

Your Only Move Is HUSTLE
Shared: Strategy · Action · 2D

Risk of Rain (2013)
Shared: Action Roguelike · Action · Pixel Graphics