Games like The Tower of 21
Games like The Tower of 21 include Buckshot Roulette, The Binding of Isaac: Rebirth, Dead Cells, Balatro, and Slots & Daggers. We matched them by the tags players give The Tower of 21 on Steam (Gambling, Action, Strategy, Card Game, and Roguelike): closest matches first, and among equally close ones the better-known games.

Buckshot Roulette
Shared: Gambling · Dark · Strategy

The Binding of Isaac: Rebirth
Shared: Roguelike · Action Roguelike · Dark

Dead Cells
Shared: Roguelike · Action Roguelike · 2D

Balatro
Shared: Card Game · Roguelike · Strategy

Slots & Daggers
Shared: Strategy · Gambling · Roguelike

Halls of Torment
Shared: Action Roguelike · Action · Roguelike

Skul: The Hero Slayer
Shared: Action · Roguelike · Action Roguelike

CloverPit
Shared: Gambling · Roguelike · Strategy

Vampire Crawlers: The Turbo Wildcard from Vampire Survivors
Shared: Strategy · Roguelike · Action

Inscryption
Shared: Card Game · Dark · Roguelike

Vampire Survivors
Shared: Action Roguelike · Roguelike · 2D

Slay the Spire 2
Shared: Card Game · Roguelike · Strategy

The Binding of Isaac
Shared: Roguelike · Action Roguelike · Action

Loop Hero
Shared: Roguelike · Card Game · Pixel Graphics

Darkest Dungeon®
Shared: Roguelike · Dark Fantasy · Strategy

Shotgun King: The Final Checkmate
Shared: Strategy · Roguelike · Action Roguelike

Slay the Spire
Shared: Card Game · Roguelike · Strategy

Death Must Die
Shared: Action Roguelike · Action · Roguelike

Risk of Rain (2013)
Shared: Action · Roguelike · Action Roguelike

Rogue Legacy
Shared: Action · Roguelike · Action Roguelike

Dungreed
Shared: Action · Roguelike · Action Roguelike

Megabonk
Shared: Roguelike · Action Roguelike · Action

Stoneshard
Shared: Strategy · Roguelike · Pixel Graphics

DARK SOULS™: REMASTERED
Shared: Action · Dark Fantasy · Dark