Games like The Synergist
Games like The Synergist include Death Must Die, Vampire Survivors, Halls of Torment, Black Myth: Wukong, and Nordic Ashes: Survivors of Ragnarok. We matched them by the tags players give The Synergist on Steam (Bullet Hell, Roguelite, Perma Death, PvE, and RPG): closest matches first, and among equally close ones the better-known games.

Death Must Die
Shared: Bullet Hell · Roguelite · RPG

Vampire Survivors
Shared: Bullet Hell · Roguelite · 2D

Halls of Torment
Shared: Roguelite · Bullet Hell · Action RPG

Black Myth: Wukong
Shared: Action RPG · RPG · Action

Nordic Ashes: Survivors of Ragnarok
Shared: Bullet Hell · Roguelite · Action RPG

Soulstone Survivors
Shared: Roguelite · Bullet Hell · Action RPG

Hero Siege
Shared: Action RPG · RPG · Pixel Graphics

Diablo® IV
Shared: Action RPG · RPG · Isometric

God Of Weapons
Shared: Roguelite · Bullet Hell · RPG

Hades II
Shared: Roguelite · Action · RPG

Heroes of Hammerwatch II
Shared: RPG · Action RPG · Roguelite

Dragon's Dogma 2
Shared: RPG · Action RPG · Action

Wolcen: Lords of Mayhem
Shared: Action RPG · RPG · Isometric

Noobs Want to Live
Shared: Bullet Hell · Roguelite · Action

Tower of Babel: Survivors of Chaos
Shared: Bullet Hell · Roguelite · Action

UnderMine
Shared: Roguelite · RPG · Action

Last Epoch
Shared: Action RPG · RPG · Isometric

Boneraiser Minions
Shared: Bullet Hell · Roguelite · 2D

Hades
Shared: Roguelite · Action · RPG

Conquest Dark
Shared: Roguelite · Bullet Hell · Action RPG

DELTARUNE
Shared: Bullet Hell · RPG · 2D

Path of Exile 2
Shared: Action RPG · RPG · Isometric

Cultivation Story: Reincarnation
Shared: Roguelite · Bullet Hell · RPG

The Slormancer
Shared: Action RPG · RPG · Action-Adventure