Games like The Smile Alchemist
Games like The Smile Alchemist include Stardew Valley, Unpacking, Little Witch in the Woods, DAVE THE DIVER, and Papers, Please. We matched them by the tags players give The Smile Alchemist on Steam (Simulation, Story Rich, Pixel Graphics, Crafting, and Singleplayer): closest matches first, and among equally close ones the better-known games.

Stardew Valley
Shared: Pixel Graphics · Simulation · Farming Sim

Unpacking
Shared: Pixel Graphics · Cute · Story Rich

Little Witch in the Woods
Shared: Pixel Graphics · Simulation · Cute

DAVE THE DIVER
Shared: Pixel Graphics · Casual · Singleplayer

Papers, Please
Shared: Simulation · Pixel Graphics · Singleplayer

Graveyard Keeper
Shared: Pixel Graphics · Simulation · Crafting

OneShot
Shared: Story Rich · Pixel Graphics · Cute

My Time at Portia
Shared: Simulation · Crafting · Life Sim

Potion Craft: Alchemist Simulator
Shared: Simulation · Crafting · Singleplayer

Travellers Rest
Shared: Pixel Graphics · Crafting · Life Sim

Fields of Mistria
Shared: Pixel Graphics · Simulation · Farming Sim

Sun Haven
Shared: Pixel Graphics · Farming Sim · Life Sim

Littlewood
Shared: Pixel Graphics · Simulation · Crafting

Undertale
Shared: Story Rich · Pixel Graphics · Singleplayer

The Test
Shared: Simulation · Story Rich · Pixel Graphics

Touhou Mystia's Izakaya
Shared: Simulation · Pixel Graphics · Casual

Dressmaker
Shared: Crafting · Simulation · Singleplayer

Potion Permit
Shared: Singleplayer · Pixel Graphics · Crafting

Clanfolk
Shared: Pixel Graphics · Simulation · Crafting

To the Moon
Shared: Story Rich · Pixel Graphics · Singleplayer

The Escapists
Shared: Pixel Graphics · Crafting · Simulation

Emily is Away Too
Shared: Simulation · Pixel Graphics · Story Rich

Volcano Princess
Shared: Simulation · Life Sim · Story Rich

Sticky Business
Shared: Simulation · Casual · Cute