Games like The Pyraplex
Games like The Pyraplex include Manor Lords, Banished, Stardew Valley, Prison Architect, and Two Point Museum. We matched them by the tags players give The Pyraplex on Steam (Simulation, Strategy, Casual, Colony Sim, and Life Sim): closest matches first, and among equally close ones the better-known games.

Manor Lords
Shared: Strategy · Simulation · City Builder

Banished
Shared: Strategy · Simulation · Colony Sim

Stardew Valley
Shared: Pixel Graphics · Simulation · Life Sim

Prison Architect
Shared: Simulation · Strategy · Colony Sim

Two Point Museum
Shared: Simulation · Casual · Strategy

Cities: Skylines
Shared: Simulation · Strategy · City Builder

Against the Storm
Shared: Simulation · Strategy · City Builder

Workers & Resources: Soviet Republic
Shared: Strategy · Simulation · City Builder

Dawn of Man
Shared: Strategy · Colony Sim · Simulation

Ostriv
Shared: Strategy · Simulation · Colony Sim

Frostpunk
Shared: Strategy · City Builder · Colony Sim

TheoTown
Shared: Simulation · Strategy · Pixel Graphics

Oxygen Not Included
Shared: Colony Sim · Simulation · Strategy

BidKing
Shared: Strategy · Simulation · Casual

Empires of the Undergrowth
Shared: Simulation · Strategy · Colony Sim

Dream Town Island
Shared: Simulation · Strategy · Casual

Kingdoms and Castles
Shared: Colony Sim · Simulation · Strategy

Cities: Skylines II
Shared: Simulation · City Builder · Strategy

Farthest Frontier
Shared: Strategy · City Builder · Colony Sim

Mini Motorways
Shared: Simulation · Strategy · Casual

Foundation
Shared: Simulation · Strategy · City Builder

Minami Lane
Shared: Casual · Simulation · Life Sim

Norland
Shared: Simulation · Strategy · Colony Sim

Plague Inc: Evolved
Shared: Simulation · Strategy · Casual

