Games like The Next Penelope
Games like The Next Penelope include SpeedRunners, Bright Memory: Infinite, Hollow Knight: Silksong, GRIP: Combat Racing, and Hotline Miami. We matched them by the tags players give The Next Penelope on Steam (Racing, Action, Indie, 4 Player Local, and Female Protagonist): closest matches first, and among equally close ones the better-known games.

SpeedRunners
Shared: Racing · Indie · Local Multiplayer

Bright Memory: Infinite
Shared: Action · Female Protagonist · Indie

Hollow Knight: Silksong
Shared: Indie · Difficult · Female Protagonist

GRIP: Combat Racing
Shared: Racing · Action · Indie

Hotline Miami
Shared: Action · Indie · Top-Down

Distance
Shared: Racing · Indie · Action

Touhou Koumakyou: New Classic - the Embodiment of Scarlet Devil
Shared: Female Protagonist · Action · Shoot 'Em Up

Devil Slayer - Raksasi
Shared: Action · Female Protagonist · Difficult

The Binding of Isaac
Shared: Indie · Action · Difficult

Celeste
Shared: Indie · Difficult · Female Protagonist

ICEY
Shared: Action · Female Protagonist · Indie

Timberman
Shared: Indie · Action · Local Multiplayer

Touhou Fuujinroku ~ Mountain of Faith.
Shared: Action · Indie · Female Protagonist

Gang Beasts
Shared: Action · Local Multiplayer · Indie

Skul: The Hero Slayer
Shared: Action · Indie · Singleplayer

Retrowave
Shared: Racing · Indie · Action

Stick Fight: The Game
Shared: Action · Local Multiplayer · 4 Player Local

Hotline Miami 2: Wrong Number
Shared: Action · Indie · Top-Down

Cube Destroyer
Shared: Action · Indie · Shoot 'Em Up

Move or Die
Shared: Action · Local Multiplayer · 4 Player Local

Circuit Superstars
Shared: Racing · Top-Down · Indie

Duck Game
Shared: Action · Local Multiplayer · 4 Player Local

TouHou Makuka Sai ~ Fantastic Danmaku Festival Part II
Shared: Indie · Shoot 'Em Up · Action

Sonic Racing: CrossWorlds
Shared: Racing · Local Multiplayer · Singleplayer