Games like The Little Slime
Games like The Little Slime include Skul: The Hero Slayer, Risk of Rain (2013), Katana ZERO, BlazBlue Entropy Effect, and Broforce. We matched them by the tags players give The Little Slime on Steam (Indie, Action, Platformer, Perma Death, and 2D): closest matches first, and among equally close ones the better-known games.

Skul: The Hero Slayer
Shared: Indie · Action · Pixel Graphics

Risk of Rain (2013)
Shared: Indie · Platformer · Action

Katana ZERO
Shared: Action · Pixel Graphics · Platformer

BlazBlue Entropy Effect
Shared: Action · 2D · Platformer

Broforce
Shared: Action · Pixel Graphics · 2D

Rogue Legacy
Shared: Indie · Platformer · Action

Noita
Shared: Indie · Pixel Graphics · Roguelike

Dead Cells
Shared: 2D · Pixel Graphics · Roguelike

Spelunky
Shared: Platformer · Indie · 2D

Hollow Knight
Shared: Platformer · Indie · 2D

Magicite
Shared: Indie · 2D · Pixel Graphics

Shovel Knight: Treasure Trove
Shared: Platformer · Indie · Pixel Graphics

Dungreed
Shared: Action · Indie · Pixel Graphics

Hades
Shared: Indie · Action · Hack and Slash

Vampire Survivors
Shared: Indie · Pixel Graphics · 2D

SANABI
Shared: Action · Pixel Graphics · Indie

Dust: An Elysian Tail
Shared: Action · Platformer · Indie

Celeste
Shared: Indie · Platformer · Pixel Graphics

The Binding of Isaac: Rebirth
Shared: Indie · Roguelike · Pixel Graphics

Super Meat Boy
Shared: Platformer · Indie · Pixel Graphics

ScourgeBringer
Shared: Indie · Action · Pixel Graphics

Blade Assault
Shared: Action · Platformer · Pixel Graphics

Hero Siege
Shared: Pixel Graphics · Hack and Slash · Indie

Duck Game
Shared: Action · Pixel Graphics · Indie