Games like The Great Plague Exodus
Games like The Great Plague Exodus include Crusader Kings III, This War of Mine, Youtubers Life, Growing Up, and 鬼谷八荒 Tale of Immortal. We matched them by the tags players give The Great Plague Exodus on Steam (Simulation, Life Sim, Interactive Fiction, Choices Matter, and Character Customization): closest matches first, and among equally close ones the better-known games.

Crusader Kings III
Shared: Simulation · Life Sim · Management

This War of Mine
Shared: Simulation · Choices Matter · Survival

Youtubers Life
Shared: Life Sim · Simulation · Management

Growing Up
Shared: Life Sim · Simulation · Choices Matter

鬼谷八荒 Tale of Immortal
Shared: Simulation · Management · Choose Your Own Adventure

The Life and Suffering of Sir Brante
Shared: Choices Matter · Interactive Fiction · Choose Your Own Adventure

The Sims™ 4
Shared: Life Sim · Simulation · Character Customization

Death and Taxes
Shared: Simulation · Choices Matter · Story Rich

Oxygen Not Included
Shared: Simulation · Management · Resource Management

Supermarket Simulator
Shared: Simulation · Management · Life Sim

Volcano Princess
Shared: Life Sim · Choices Matter · Simulation

RimWorld
Shared: Simulation · Management · Survival

Potion Craft: Alchemist Simulator
Shared: Simulation · Management · 2D

CHANGE: A Homeless Survival Experience
Shared: Life Sim · Choose Your Own Adventure · Character Customization

The Pale Beyond
Shared: Choices Matter · Simulation · Resource Management

The Sims™ 3
Shared: Simulation · Life Sim · Character Customization

Cities: Skylines
Shared: Simulation · Management · Strategy

911 Operator
Shared: Simulation · Management · Choices Matter

I Was a Teenage Exocolonist
Shared: Life Sim · Choices Matter · Interactive Fiction

Frostpunk
Shared: Resource Management · Simulation · Survival

inZOI
Shared: Life Sim · Simulation · Character Customization

Frostpunk 2
Shared: Simulation · Resource Management · Management

Reigns
Shared: Choices Matter · Life Sim · Simulation

60 Seconds! Reatomized
Shared: Choose Your Own Adventure · 2D · Simulation