Games like The Entropy Directive
Games like The Entropy Directive include Balatro, Slay the Spire, Slay the Spire 2, Inscryption, and Monster Train. We matched them by the tags players give The Entropy Directive on Steam (Casual, Strategy, Card Game, Education, and Roguelike): closest matches first, and among equally close ones the better-known games.

Balatro
Shared: Card Game · Roguelike · Strategy

Slay the Spire
Shared: Card Game · Roguelike · Card Battler

Slay the Spire 2
Shared: Card Game · Roguelike · Strategy

Inscryption
Shared: Card Game · Card Battler · Strategy

Monster Train
Shared: Card Game · Card Battler · Roguelite

DICEOMANCER
Shared: Strategy · Card Game · Card Battler

Dungeons & Degenerate Gamblers
Shared: Strategy · Card Game · Roguelike

9 Kings
Shared: Strategy · Card Game · Roguelike

Vampire Crawlers: The Turbo Wildcard from Vampire Survivors
Shared: Strategy · Card Battler · Roguelike

Stacklands
Shared: Card Game · Strategy · Card Battler

Ratropolis
Shared: Strategy · Card Battler · Card Game

Wildfrost
Shared: Card Game · Card Battler · Turn-Based Tactics

Dicey Dungeons
Shared: Card Battler · Roguelike · Strategy

Ballionaire
Shared: Casual · Strategy · Roguelike

Roguebook
Shared: Card Game · Strategy · Indie

Slots & Daggers
Shared: Casual · Strategy · Roguelike

RACCOIN: Coin Pusher Roguelike
Shared: Strategy · Roguelike · Casual

Dream of Corpse Lady
Shared: Strategy · Card Game · Card Battler

Die in the Dungeon
Shared: Strategy · Roguelike · Card Game

Vampire Survivors
Shared: Roguelite · Casual · Roguelike

Griftlands
Shared: Card Battler · Card Game · Roguelite

Across the Obelisk
Shared: Casual · Card Game · Roguelike

Breachway
Shared: Strategy · Card Game · Roguelike

Super Fantasy Kingdom
Shared: Strategy · Roguelike · Card Game