Games like System Purge
Games like System Purge include Celeste, CARRION, Blasphemous, Resident Evil 3, and Hollow Knight: Silksong. We matched them by the tags players give System Purge on Steam (Platformer, Female Protagonist, 2D, Horror, and Action): closest matches first, and among equally close ones the better-known games.

Celeste
Shared: Platformer · Pixel Graphics · Female Protagonist

CARRION
Shared: Pixel Graphics · Action · Horror

Blasphemous
Shared: 2D · Pixel Graphics · Platformer

Resident Evil 3
Shared: Female Protagonist · Action · Horror

Hollow Knight: Silksong
Shared: 2D · Platformer · Female Protagonist

Super Meat Boy
Shared: Platformer · 2D · Pixel Graphics

Katana ZERO
Shared: Platformer · Action · Pixel Graphics

Skul: The Hero Slayer
Shared: Action · 2D · Pixel Graphics

Hollow Knight
Shared: Platformer · 2D · Singleplayer

Resident Evil 2
Shared: Horror · Zombies · Action

Broforce
Shared: Action · 2D · Platformer

Resident Evil 4
Shared: Horror · Action · Zombies

Freedom Planet
Shared: Platformer · Female Protagonist · 2D

Shovel Knight: Treasure Trove
Shared: Platformer · Pixel Graphics · 2D

Valfaris
Shared: Platformer · Action · 2D

Bloodstained: Curse of the Moon
Shared: Platformer · Action · 2D

SANABI
Shared: Pixel Graphics · Action · 2D

Axiom Verge
Shared: Platformer · Pixel Graphics · 2D

LIMBO
Shared: Platformer · 2D · Indie

Lost Ruins
Shared: Platformer · Pixel Graphics · Action

Hotline Miami
Shared: Action · Pixel Graphics · Indie

Iconoclasts
Shared: Female Protagonist · Pixel Graphics · Platformer

The Messenger
Shared: Platformer · 2D · Pixel Graphics

People Playground
Shared: 2D · Gore · Singleplayer