Games like Street Defenders
Games like Street Defenders include Bloons TD 6, Plants vs. Zombies GOTY Edition, Kingdom Rush - Tower Defense, Skul: The Hero Slayer, and Hades. We matched them by the tags players give Street Defenders on Steam (Action Roguelike, Tactical RPG, Tower Defense, Action, and Difficult): closest matches first, and among equally close ones the better-known games.

Bloons TD 6
Shared: Tower Defense · Strategy · Difficult

Plants vs. Zombies GOTY Edition
Shared: Tower Defense · Strategy · 2D

Kingdom Rush - Tower Defense
Shared: Tower Defense · Strategy · Action

Skul: The Hero Slayer
Shared: Action Roguelike · Action · 2D

Hades
Shared: Action Roguelike · Action · Indie

Bloons TD 5
Shared: Tower Defense · Action · Strategy

Kingdom Rush Vengeance - Tower Defense
Shared: Tower Defense · Difficult · Strategy

The Binding of Isaac: Rebirth
Shared: Action Roguelike · Difficult · Indie

Kingdom Rush Frontiers - Tower Defense
Shared: Tower Defense · Difficult · Strategy

The Binding of Isaac
Shared: Action Roguelike · Difficult · Action

The Last Spell
Shared: RPG · Strategy · Tactical RPG

Kingdom Rush Origins - Tower Defense
Shared: Tower Defense · Difficult · Strategy

Kingdom Rush 5: Alliance TD
Shared: Tower Defense · Strategy · 2D

Vampire Survivors
Shared: Action Roguelike · 2D · Action

The Banner Saga
Shared: Tactical RPG · Strategy RPG · RPG

Orcs Must Die! 2
Shared: Tower Defense · Action · Strategy

Tangy TD
Shared: Tower Defense · Action · Strategy

Risk of Rain (2013)
Shared: Action Roguelike · Action · Difficult

Dungreed
Shared: Action Roguelike · Action · Difficult

The Escapists
Shared: Strategy · Action · Difficult

Enter the Gungeon
Shared: Action Roguelike · Difficult · Action

Cult of the Lamb
Shared: Action Roguelike · Cute · Action

Orcs Must Die!
Shared: Tower Defense · Action · Strategy

GemCraft - Chasing Shadows
Shared: Tower Defense · Action · Strategy