Games like Spook n Loot
Games like Spook n Loot include Skul: The Hero Slayer, Vampire Survivors, The Binding of Isaac: Rebirth, BlazBlue Entropy Effect, and Rogue Legacy. We matched them by the tags players give Spook n Loot on Steam (Action, Pixel Graphics, 2D Fighter, Action Roguelike, and Singleplayer): closest matches first, and among equally close ones the better-known games.

Skul: The Hero Slayer
Shared: Action · Pixel Graphics · Action Roguelike

Vampire Survivors
Shared: Action Roguelike · Pixel Graphics · 2D

The Binding of Isaac: Rebirth
Shared: Action Roguelike · Pixel Graphics · Indie

BlazBlue Entropy Effect
Shared: Action · Action Roguelike · 2D

Rogue Legacy
Shared: Action · Action Roguelike · Singleplayer

Your Only Move Is HUSTLE
Shared: Action · 2D Fighter · Pixel Graphics

Sephiria
Shared: Action Roguelike · Pixel Graphics · Action

Dungreed
Shared: Pixel Graphics · Action Roguelike · Action

UnderMine
Shared: Pixel Graphics · Action Roguelike · Action

SANABI
Shared: Pixel Graphics · Action · Singleplayer

Dead Cells
Shared: Pixel Graphics · Action Roguelike · 2D

Cult of the Lamb
Shared: Action Roguelike · Singleplayer · Cute

Enter the Gungeon
Shared: Pixel Graphics · Action Roguelike · Action

Risk of Rain (2013)
Shared: Action Roguelike · Action · Pixel Graphics

Them's Fightin' Herds
Shared: Action · 2D Fighter · Cute

Rivals of Aether
Shared: Pixel Graphics · 2D Fighter · Indie

The Binding of Isaac
Shared: Action Roguelike · Action · Indie

Halls of Torment
Shared: Action Roguelike · Pixel Graphics · Action

Katana ZERO
Shared: Action · Pixel Graphics · 2D

Hades
Shared: Action Roguelike · Action · Singleplayer

Death Must Die
Shared: Action Roguelike · Pixel Graphics · Action

Megabonk
Shared: Action Roguelike · Action · Pixel Graphics

Rocket Rats
Shared: Pixel Graphics · Action Roguelike · Action

Nuclear Throne
Shared: Pixel Graphics · Action Roguelike · Action