Games like Space Drifters 2D
Games like Space Drifters 2D include Cosmoteer: Starship Architect & Commander, FTL: Faster Than Light, Hollow Knight: Silksong, Defy Gravity Extended, and Among Us. We matched them by the tags players give Space Drifters 2D on Steam (Indie, 2D, and Space): closest matches first, and among equally close ones the better-known games.

Cosmoteer: Starship Architect & Commander
Shared: Space · 2D · Indie

FTL: Faster Than Light
Shared: Space · Indie · 2D

Hollow Knight: Silksong
Shared: Indie · 2D

Defy Gravity Extended
Shared: Indie · Space · 2D

Among Us
Shared: Space · 2D

Reassembly
Shared: Space · 2D · Indie

Heat Signature
Shared: Indie · Space · 2D

Firework
Shared: Indie · 2D

Skul: The Hero Slayer
Shared: Indie · 2D

Hollow Knight
Shared: 2D · Indie

Solar 2
Shared: Indie · Space · 2D

The Binding of Isaac: Rebirth
Shared: Indie · 2D

Vampire Survivors
Shared: 2D · Indie

Space Pirates and Zombies
Shared: Indie · Space · 2D

LIMBO
Shared: Indie · 2D

Spaceflight Simulator
Shared: Space · 2D · Indie

Starbound
Shared: Space · Indie · 2D

Endless Sky
Shared: Space · 2D · Indie

Kerbal Space Program
Shared: Space · Indie

OPUS: Echo of Starsong - Full Bloom Edition
Shared: Indie · 2D · Space

Oxygen Not Included
Shared: 2D · Space · Indie

Crying Suns
Shared: Space · Indie · 2D

Awesomenauts
Shared: 2D · Indie · Space

Streets of Rage 4
Shared: Indie · 2D