Games like Space Civilization Clicker
Games like Space Civilization Clicker include Nodebuster, A Game About Feeding A Black Hole, Cosmoteer: Starship Architect & Commander, Oxygen Not Included, and Digseum. We matched them by the tags players give Space Civilization Clicker on Steam (2D, Point & Click, Space, Idler, and Simulation): closest matches first, and among equally close ones the better-known games.

Nodebuster
Shared: Idler · 2D · Simulation

A Game About Feeding A Black Hole
Shared: 2D · Relaxing · Idler

Cosmoteer: Starship Architect & Commander
Shared: 2D · Space · Strategy

Oxygen Not Included
Shared: 2D · Colony Sim · Simulation

Digseum
Shared: Idler · Simulation · Relaxing

Shelldiver
Shared: 2D · Idler · Relaxing

Papers, Please
Shared: Point & Click · Simulation · 2D

Click the Button
Shared: Idler · Point & Click · Simulation

Loot Loop
Shared: Idler · Simulation · Relaxing

Cookie Clicker
Shared: Idler · 2D · Casual

Samorost 1
Shared: Point & Click · Space · 2D

Game Dev Tycoon
Shared: Simulation · 2D · Strategy

Kerbal Space Program
Shared: Space · Simulation · Building

Tower Wizard
Shared: Idler · 2D · Strategy

Planet Coaster
Shared: Simulation · Relaxing · Strategy

FTL: Faster Than Light
Shared: Space · Strategy · Sci-fi

Rusty's Retirement
Shared: Idler · Simulation · Relaxing

Prison Architect
Shared: Simulation · 2D · Strategy

Click and Conquer
Shared: Idler · Simulation · 2D

Zero Stress King: Idle Defense
Shared: Idler · 2D · Strategy

Dyson Sphere Program
Shared: Space · Simulation · Building

Universe Sandbox
Shared: Space · Simulation · Relaxing

(the) Gnorp Apologue
Shared: Idler · Strategy · 2D

Stellaris
Shared: Space · Strategy · Simulation