Games like Space Adventure - Escape from Siphilus 1b
Games like Space Adventure - Escape from Siphilus 1b include There Is No Game: Wrong Dimension, Deponia, Broken Age, Space Pilgrim Episode I: Alpha Centauri, and Deponia: The Complete Journey. We matched them by the tags players give Space Adventure - Escape from Siphilus 1b on Steam (Adventure, Point & Click, Sci-fi, Space, and Puzzle Platformer): closest matches first, and among equally close ones the better-known games.

There Is No Game: Wrong Dimension
Shared: Point & Click · Adventure · Comedy

Deponia
Shared: Adventure · Point & Click · Comedy

Broken Age
Shared: Adventure · Point & Click · Comedy

Space Pilgrim Episode I: Alpha Centauri
Shared: Adventure · Sci-fi · Space

Deponia: The Complete Journey
Shared: Adventure · Point & Click · Comedy

Return to Monkey Island
Shared: Adventure · Point & Click · Comedy

Primordia
Shared: Adventure · Point & Click · Sci-fi

Thank Goodness You're Here!
Shared: Adventure · Comedy · 2D Platformer

Chaos on Deponia
Shared: Adventure · Point & Click · Comedy

Tales from the Borderlands
Shared: Adventure · Comedy · Point & Click

The Swapper
Shared: Sci-fi · Space · Adventure

McPixel 3
Shared: Adventure · Point & Click · 2D

SANABI
Shared: Adventure · 2D Platformer · Cyberpunk

Deponia Doomsday
Shared: Adventure · Point & Click · Comedy

Outer Wilds
Shared: Space · Adventure · Sci-fi

Portal
Shared: Puzzle Platformer · Sci-fi · Comedy

No Man's Sky
Shared: Space · Sci-fi · Adventure

Paradigm
Shared: Adventure · Point & Click · Comedy

Thimbleweed Park™
Shared: Adventure · Point & Click · Comedy

The Silent Age
Shared: Point & Click · Adventure · Sci-fi

The Secret of Monkey Island: Special Edition
Shared: Adventure · Point & Click · Comedy

Goodbye Deponia
Shared: Adventure · Point & Click · Comedy

Lair of the Clockwork God
Shared: Adventure · Point & Click · Comedy

Lil' Guardsman
Shared: Adventure · Point & Click · Comedy