Games like Slime Killer
Games like Slime Killer include Skul: The Hero Slayer, The Binding of Isaac: Rebirth, Spelunky, Vampire Survivors, and Hollow Knight. We matched them by the tags players give Slime Killer on Steam (Action Roguelike, Arena Shooter, Exploration, Top-Down Shooter, and Auto Battler): closest matches first, and among equally close ones the better-known games.

Skul: The Hero Slayer
Shared: Action Roguelike · Roguelike · Action

The Binding of Isaac: Rebirth
Shared: Action Roguelike · Difficult · Roguelike

Spelunky
Shared: Action Roguelike · Platformer · Difficult

Vampire Survivors
Shared: Action Roguelike · 2D · Roguelike

Hollow Knight
Shared: Platformer · Difficult · Exploration

Dead Cells
Shared: Action Roguelike · Roguelike · 2D

Rogue Legacy
Shared: Action Roguelike · Platformer · Roguelike

Risk of Rain (2013)
Shared: Action Roguelike · Platformer · Roguelike

Enter the Gungeon
Shared: Action Roguelike · Difficult · Roguelike

Nuclear Throne
Shared: Action Roguelike · Difficult · Roguelike

Hollow Knight: Silksong
Shared: Difficult · Exploration · Platformer

Rain World
Shared: Exploration · Difficult · Platformer

Downwell
Shared: Action Roguelike · Platformer · Arcade

BALL x PIT
Shared: Action Roguelike · Arcade · Top-Down Shooter

Dungreed
Shared: Action Roguelike · Roguelike · Difficult

Brotato
Shared: Action Roguelike · Roguelike · Arena Shooter

The Binding of Isaac
Shared: Action Roguelike · Difficult · Roguelike

Noita
Shared: Difficult · Roguelike · Action Roguelike

Rogue Legacy 2
Shared: Arcade · Platformer · Difficult

Celeste
Shared: Difficult · Platformer · Indie

Megabonk
Shared: Action Roguelike · Roguelike · Indie

Airscape - The Fall of Gravity
Shared: Exploration · Difficult · Platformer

Tiny Rogues
Shared: Action Roguelike · Top-Down Shooter · Difficult

Nordic Ashes: Survivors of Ragnarok
Shared: Action Roguelike · Exploration · Roguelike