Games like Slay the Spire 2
Games like Slay the Spire 2 include Slay the Spire, Balatro, 9 Kings, Die in the Dungeon, and Monster Train. We matched them by the tags players give Slay the Spire 2 on Steam (Roguelike, Card Game, Deckbuilding, Strategy, and Roguelike Deckbuilder): closest matches first, and among equally close ones the better-known games.

Slay the Spire
Shared: Card Game · Roguelike · Roguelike Deckbuilder

Balatro
Shared: Roguelike · Card Game · Deckbuilding

9 Kings
Shared: Roguelike · Strategy · Card Game

Die in the Dungeon
Shared: Roguelike · Deckbuilding · Card Game

Monster Train
Shared: Card Game · Deckbuilding · Roguelike

Dicey Dungeons
Shared: Deckbuilding · Roguelike · Roguelike Deckbuilder

Vampire Crawlers: The Turbo Wildcard from Vampire Survivors
Shared: Roguelike · Deckbuilding · Card Game

Inscryption
Shared: Card Game · Deckbuilding · Roguelike

Super Fantasy Kingdom
Shared: Roguelike · Strategy · Card Game

HELLCARD
Shared: Roguelike · Co-op · Deckbuilding

Wildfrost
Shared: Card Game · Roguelike Deckbuilder · Roguelike

Breachway
Shared: Roguelike · Card Game · Strategy

Dungeons & Degenerate Gamblers
Shared: Roguelike · Card Game · Roguelike Deckbuilder

He is Coming
Shared: Roguelike · Strategy · Card Game

Monster Train 2
Shared: Card Game · Roguelike · Deckbuilding

Library Of Ruina
Shared: Card Game · Deckbuilding · Strategy

Roguebook
Shared: Card Game · Deckbuilding · Roguelike

Astrea: Six-Sided Oracles
Shared: Card Game · Roguelike · Roguelike Deckbuilder

Vault of the Void
Shared: Deckbuilding · Roguelike Deckbuilder · Card Game

DICEOMANCER
Shared: Card Game · Strategy · Roguelike

Ratropolis
Shared: Deckbuilding · Card Game · Strategy

Griftlands
Shared: Deckbuilding · Card Game · Card Battler

As We Descend
Shared: Card Game · Roguelike · Roguelike Deckbuilder

My Card Is Better Than Your Card!
Shared: Roguelike · Card Game · Deckbuilding