Games like Sipho
Games like Sipho include Hades, Totally Accurate Battle Simulator, Space Engineers, Feed and Grow: Fish, and We Who Are About To Die. We matched them by the tags players give Sipho on Steam (Action Roguelike, Action, Indie, Simulation, and Strategy): closest matches first, and among equally close ones the better-known games.

Hades
Shared: Action Roguelike · Indie · Action

Totally Accurate Battle Simulator
Shared: Simulation · Sandbox · Strategy

Space Engineers
Shared: Sandbox · Simulation · Building

Feed and Grow: Fish
Shared: Simulation · Action · Underwater

We Who Are About To Die
Shared: Action · Simulation · Strategy

Everything is Crab: The Animal Evolution Roguelite
Shared: Action Roguelike · Strategy · Roguelite

Noita
Shared: Indie · Sandbox · Action Roguelike

Megabonk
Shared: Action Roguelike · Indie · Action

Total Tank Simulator
Shared: Action · Simulation · Strategy

Cultivation Tales
Shared: Action · Sandbox · Building

Banished
Shared: Simulation · Strategy · Indie

Planet Coaster
Shared: Simulation · Sandbox · Building

Skul: The Hero Slayer
Shared: Action · Action Roguelike · Indie

Primordialis
Shared: Action Roguelike · Simulation · Sandbox

Garry's Mod
Shared: Sandbox · Building · Simulation

Jurassic World Evolution
Shared: Simulation · Strategy · Building

Kerbal Space Program
Shared: Simulation · Sandbox · Indie

Vampire Survivors
Shared: Action Roguelike · Indie · Roguelite

Kenshi
Shared: Sandbox · Simulation · Survival

Mount & Blade II: Bannerlord
Shared: Strategy · Action · Sandbox

Cities: Skylines
Shared: Simulation · Strategy · Sandbox

House Flipper
Shared: Simulation · Sandbox · Building

RimWorld
Shared: Strategy · Sandbox · Simulation

People Playground
Shared: Sandbox · Simulation · Physics