Games like Shot Up!
Games like Shot Up! include SANABI, Celeste, Downwell, UFO 50, and Broforce. We matched them by the tags players give Shot Up! on Steam (Action, Adventure, Casual, Indie, and 2D Fighter): closest matches first, and among equally close ones the better-known games.

SANABI
Shared: Action · Adventure · 2D Platformer

Celeste
Shared: Precision Platformer · Indie · 2D Platformer

Downwell
Shared: Indie · Precision Platformer · Action

UFO 50
Shared: Action · Indie · Adventure

Broforce
Shared: Action · Indie · 2D

Super Meat Boy
Shared: Indie · Precision Platformer · 2D Platformer

Planet of Lana
Shared: Action · Puzzle Platformer · 2D Platformer

Sonic Origins
Shared: Action · Adventure · 2D Platformer

Super Bernie World
Shared: Action · Adventure · Indie

Skul: The Hero Slayer
Shared: Action · Indie · 2D

Shovel Knight: Treasure Trove
Shared: Indie · Adventure · Action

Cyberhunt
Shared: Action · Indie · Casual

Jump King
Shared: Indie · Adventure · Precision Platformer

Kung Fury: Street Rage - Ultimate Edition
Shared: Action · Indie · Adventure

Pikuniku
Shared: Adventure · Indie · Casual

VVVVVV
Shared: Indie · Precision Platformer · 2D Platformer

MO:Astray
Shared: Action · Adventure · Indie

Janosik
Shared: Action · Adventure · Casual

Pizza Tower
Shared: Indie · 2D Platformer · Action

LIMBO
Shared: Indie · Puzzle Platformer · Adventure

Webbed
Shared: 2D Platformer · Puzzle Platformer · Action

Exit the Gungeon
Shared: Action · Adventure · Indie

Your Only Move Is HUSTLE
Shared: Action · 2D Fighter · 2D

Super Fancy Pants Adventure
Shared: Action · Adventure · Indie