Games like Shad'O
Games like Shad'O include Orcs Must Die!, Orcs Must Die! 2, GemCraft - Chasing Shadows, Kingdom Rush - Tower Defense, and Bloons TD 6. We matched them by the tags players give Shad'O on Steam (Indie, Tower Defense, Strategy, Action, and Singleplayer): closest matches first, and among equally close ones the better-known games.

Orcs Must Die!
Shared: Tower Defense · Strategy · Action

Orcs Must Die! 2
Shared: Tower Defense · Strategy · Action

GemCraft - Chasing Shadows
Shared: Tower Defense · Indie · Strategy

Kingdom Rush - Tower Defense
Shared: Tower Defense · Strategy · Singleplayer

Bloons TD 6
Shared: Tower Defense · Strategy · Singleplayer

Plants vs. Zombies GOTY Edition
Shared: Tower Defense · Strategy · Singleplayer

Kingdom Rush 5: Alliance TD
Shared: Tower Defense · Strategy · Singleplayer

Infested Planet
Shared: Tower Defense · Strategy · Indie

Defense Grid: The Awakening
Shared: Tower Defense · Strategy · Indie

Sanctum 2
Shared: Tower Defense · Strategy · Action

X-Morph: Defense
Shared: Tower Defense · Strategy · Indie

Rock 'N' Roll Defense
Shared: Tower Defense · Strategy · Action

Taur
Shared: Tower Defense · Strategy · Indie

Bloons TD 5
Shared: Tower Defense · Strategy · Action

Rock of Ages
Shared: Indie · Strategy · Tower Defense

Sang-Froid - Tales of Werewolves
Shared: Strategy · Tower Defense · Indie

Mount & Blade II: Bannerlord
Shared: Strategy · Singleplayer · Action

Space Run
Shared: Tower Defense · Strategy · Indie

Kingdom Rush Frontiers - Tower Defense
Shared: Tower Defense · Strategy · Singleplayer

Dungeon Defenders
Shared: Tower Defense · Strategy · Singleplayer

Thronefall
Shared: Tower Defense · Strategy · Action

Anomaly Warzone Earth
Shared: Indie · Strategy · Tower Defense

Creeper World 3: Arc Eternal
Shared: Tower Defense · Indie · Strategy

Rock of Ages 2: Bigger & Boulder™
Shared: Strategy · Indie · Action