Games like Serious Sam: The Random Encounter
Games like Serious Sam: The Random Encounter include South Park™: The Stick of Truth™, Undertale, DELTARUNE, Dungeon Munchies, and Yakuza: Like a Dragon. We matched them by the tags players give Serious Sam: The Random Encounter on Steam (Action, Indie, RPG, Turn-Based, and 2D): closest matches first, and among equally close ones the better-known games.

South Park™: The Stick of Truth™
Shared: RPG · Action · Turn-Based

Undertale
Shared: RPG · Indie · Pixel Graphics

DELTARUNE
Shared: RPG · Pixel Graphics · Singleplayer

Dungeon Munchies
Shared: Action · Indie · RPG

Yakuza: Like a Dragon
Shared: Action · RPG · Turn-Based

Epic Battle Fantasy 4
Shared: Indie · Turn-Based · RPG

Epic Battle Fantasy 5
Shared: Indie · Turn-Based · JRPG

Skul: The Hero Slayer
Shared: Action · Indie · 2D

Vampire Survivors
Shared: Indie · 2D · Pixel Graphics

Chained Echoes
Shared: RPG · Turn-Based · Indie

Cthulhu Saves the World
Shared: RPG · Indie · JRPG

UnEpic
Shared: Indie · RPG · Action

Gunpoint
Shared: Indie · 2D · Action

Pizza Tower
Shared: Indie · Action · Pixel Graphics

The Escapists
Shared: Pixel Graphics · Indie · Action

South Park™: The Fractured But Whole™
Shared: RPG · Comedy · Turn-Based

Broforce
Shared: Action · 2D · Pixel Graphics

Doom & Destiny
Shared: Indie · RPG · Comedy

Breath of Death VII
Shared: RPG · Indie · JRPG

Evoland
Shared: Indie · RPG · Singleplayer

Knights of Pen and Paper +1 Edition
Shared: RPG · Indie · Turn-Based

Rogue Legacy
Shared: Indie · Action · Singleplayer

Rhythm Doctor
Shared: Indie · Pixel Graphics · Action

Knights of Pen and Paper 2
Shared: RPG · Turn-Based · Indie