Games like Science Monster: Grafted Heart
Games like Science Monster: Grafted Heart include Nuclear Throne, Vampire Survivors, BALL x PIT, Deep Rock Galactic: Survivor, and Enter the Gungeon. We matched them by the tags players give Science Monster: Grafted Heart on Steam (Action, Strategy, Action Roguelike, Shooter, and 2D Platformer): closest matches first, and among equally close ones the better-known games.

Nuclear Throne
Shared: Action Roguelike · Action · Bullet Hell

Vampire Survivors
Shared: Action Roguelike · Bullet Hell · 2D

BALL x PIT
Shared: Action · Action Roguelike · Bullet Hell

Deep Rock Galactic: Survivor
Shared: Action Roguelike · Top-Down Shooter · Bullet Hell

Enter the Gungeon
Shared: Action Roguelike · Bullet Hell · Action

20 Minutes Till Dawn
Shared: Action Roguelike · Bullet Hell · Top-Down Shooter

The Binding of Isaac
Shared: Action Roguelike · Action · Indie

Halo: Spartan Assault
Shared: Action · Top-Down Shooter · Shooter

BlazBlue Entropy Effect
Shared: Action · Action Roguelike · 2D

SYNTHETIK: Legion Rising
Shared: Action · Top-Down Shooter · Action Roguelike

Door Kickers
Shared: Strategy · Action · Top-Down

Gem Defender: Soyjak Survivors
Shared: Action · Shooter · Strategy

Police Stories
Shared: Action · Strategy · Top-Down Shooter

Lumencraft
Shared: Action · Strategy · Action Roguelike

The Last Stand: Aftermath
Shared: Shooter · Top-Down Shooter · Action Roguelike

Nordic Ashes: Survivors of Ragnarok
Shared: Action Roguelike · Bullet Hell · Strategy

ShellShock Live
Shared: Strategy · Action · Shooter

Roboquest
Shared: Action Roguelike · Shooter · Action

Glyphica: Typing Survival
Shared: Action Roguelike · Action · Top-Down Shooter

Halls of Torment
Shared: Action Roguelike · Action · Bullet Hell

Angel at Dusk
Shared: Action · Shooter · Bullet Hell

Skul: The Hero Slayer
Shared: Action · Action Roguelike · 2D

Pass the Fear
Shared: Action Roguelike · Strategy · Action

Aliens: Dark Descent
Shared: Strategy · Action · Top-Down