Games like Santo Island Incident
Games like Santo Island Incident include Blue Prince, Fallout 4, FAR: Lone Sails, Firewatch, and Outer Wilds. We matched them by the tags players give Santo Island Incident on Steam (Post-apocalyptic, Atmospheric, Singleplayer, Investigation, and Mystery): closest matches first, and among equally close ones the better-known games.

Blue Prince
Shared: Mystery · Puzzle · Investigation

Fallout 4
Shared: Post-apocalyptic · Singleplayer · Atmospheric

FAR: Lone Sails
Shared: Atmospheric · Post-apocalyptic · Singleplayer

Firewatch
Shared: Atmospheric · Adventure · Mystery

Outer Wilds
Shared: Mystery · Atmospheric · Exploration

Sherlock Holmes: The Devil's Daughter
Shared: Mystery · Adventure · Puzzle

Return of the Obra Dinn
Shared: Atmospheric · Mystery · Singleplayer

What Remains of Edith Finch
Shared: Atmospheric · Mystery · Singleplayer

The Painscreek Killings
Shared: Investigation · Mystery · Atmospheric

The House of Da Vinci
Shared: Mystery · Atmospheric · Puzzle

The Room
Shared: Atmospheric · Mystery · Puzzle

Metro Exodus
Shared: Post-apocalyptic · Singleplayer · Atmospheric

Murders on the Yangtze River
Shared: Puzzle · Mystery · Adventure

Chants of Sennaar
Shared: Singleplayer · Puzzle · Atmospheric

The Talos Principle
Shared: Puzzle · Atmospheric · Singleplayer

Fallout: New Vegas
Shared: Post-apocalyptic · Singleplayer · Exploration

S.T.A.L.K.E.R. 2: Heart of Chornobyl - Standard Edition
Shared: Post-apocalyptic · Atmospheric · Singleplayer

Sherlock Holmes: Crimes and Punishments
Shared: Investigation · Mystery · Atmospheric

Strange Horticulture
Shared: Mystery · Atmospheric · Puzzle

Quern - Undying Thoughts
Shared: Atmospheric · Mystery · Puzzle

Unheard - Voices of Crime
Shared: Mystery · Thriller · Puzzle

Stray
Shared: Atmospheric · Singleplayer · Adventure

The Room Three
Shared: Mystery · Puzzle · Atmospheric

The Room 4: Old Sins
Shared: Mystery · Puzzle · Singleplayer