Games like Sanatorium - A Mental Asylum Simulator
Games like Sanatorium - A Mental Asylum Simulator include Strange Horticulture, Return of the Obra Dinn, The Case of the Golden Idol, Papers, Please, and Tangle Tower. We matched them by the tags players give Sanatorium - A Mental Asylum Simulator on Steam (Medical Sim, Puzzle, Detective, Card Game, and Point & Click): closest matches first, and among equally close ones the better-known games.

Strange Horticulture
Shared: Puzzle · Detective · Point & Click

Return of the Obra Dinn
Shared: Detective · Puzzle · Historical

The Case of the Golden Idol
Shared: Detective · Puzzle · Point & Click

Papers, Please
Shared: Point & Click · Puzzle · Indie

Tangle Tower
Shared: Detective · Puzzle · Point & Click

The Wolf Among Us
Shared: Detective · Point & Click · Choices Matter

Inscryption
Shared: Card Game · Puzzle · Deckbuilding

The White Door
Shared: Puzzle · Detective · Point & Click

The Rewinder
Shared: Puzzle · Detective · 2D

Blacksad: Under the Skin
Shared: Puzzle · Point & Click · Detective

The Silent Age
Shared: Point & Click · Puzzle · Detective

Cyber Manhunt 2: New World - The Hacking Simulator
Shared: Puzzle · Detective · Point & Click

Murders on the Yangtze River
Shared: Puzzle · Detective · Adventure

Chants of Sennaar
Shared: Puzzle · Point & Click · Detective

Sherlock Holmes: Crimes and Punishments
Shared: Detective · Puzzle · Point & Click

Disco Elysium - The Final Cut
Shared: Detective · Point & Click · Choices Matter

The Roottrees are Dead
Shared: Puzzle · Detective · Point & Click

Cube Escape Collection
Shared: Puzzle · Point & Click · Detective

Strange Antiquities
Shared: Puzzle · Detective · Point & Click

There Is No Game: Wrong Dimension
Shared: Puzzle · Point & Click · Indie

Sherlock Holmes: The Devil's Daughter
Shared: Detective · Puzzle · Adventure

Unheard - Voices of Crime
Shared: Detective · Puzzle · Story Rich

OneShot
Shared: Puzzle · Story Rich · Indie

The Rise of the Golden Idol
Shared: Detective · Puzzle · 2D