Games like Rocket Science: Edition Upgrade
Games like Rocket Science: Edition Upgrade include Kerbal Space Program, Dyson Sphere Program, Universe Sandbox, X4: Foundations, and Hardspace: Shipbreaker. We matched them by the tags players give Rocket Science: Edition Upgrade on Steam (Simulation, Strategy, Mars, Resource Management, and Space Sim): closest matches first, and among equally close ones the better-known games.

Kerbal Space Program
Shared: Simulation · Sandbox · Space Sim

Dyson Sphere Program
Shared: Simulation · Resource Management · Strategy

Universe Sandbox
Shared: Simulation · Sandbox · Space Sim

X4: Foundations
Shared: Simulation · Space Sim · Strategy

Hardspace: Shipbreaker
Shared: Simulation · Physics · Sci-fi

Space Engineers
Shared: Simulation · Sandbox · Physics

RimWorld
Shared: Strategy · Simulation · Sandbox

Stellaris
Shared: Strategy · Simulation · Sandbox

Elite Dangerous
Shared: Space Sim · Simulation · Sci-fi

Manor Lords
Shared: Strategy · Simulation · Resource Management

Oxygen Not Included
Shared: Resource Management · Simulation · Strategy

Cities: Skylines
Shared: Simulation · Strategy · Sandbox

Kerbal Space Program 2
Shared: Sandbox · Simulation · Physics

Factorio
Shared: Resource Management · Strategy · Sandbox

Space Haven
Shared: Strategy · Simulation · Sandbox

SPORE™
Shared: Simulation · Sandbox · Open World

Totally Accurate Battle Simulator
Shared: Simulation · Strategy · Sandbox

Prison Architect
Shared: Simulation · Strategy · Sandbox

Against the Storm
Shared: Simulation · Strategy · Resource Management

SpaceEngine
Shared: Sandbox · Space Sim · Sci-fi

Jurassic World Evolution
Shared: Simulation · Strategy · Sandbox

X Rebirth
Shared: Simulation · Space Sim · Sandbox

Kingdoms and Castles
Shared: Simulation · Resource Management · Strategy

Empyrion - Galactic Survival
Shared: Simulation · Space Sim · Sandbox