Games like Return to Mysterious Island 2
Games like Return to Mysterious Island 2 include The Room, The Room 4: Old Sins, Syberia, Portal 2, and Escape Simulator. We matched them by the tags players give Return to Mysterious Island 2 on Steam (Adventure, Point & Click, Casual, Female Protagonist, and Puzzle): closest matches first, and among equally close ones the better-known games.

The Room
Shared: Point & Click · Puzzle · Adventure

The Room 4: Old Sins
Shared: Point & Click · Adventure · Puzzle

Syberia
Shared: Adventure · Point & Click · Female Protagonist

Portal 2
Shared: Puzzle · Singleplayer · First-Person

Escape Simulator
Shared: Puzzle · Adventure · First-Person

Monument Valley
Shared: Adventure · Puzzle · Casual

There Is No Game: Wrong Dimension
Shared: Point & Click · Adventure · Puzzle

The Room Three
Shared: Adventure · Point & Click · Puzzle

The Room Two
Shared: Point & Click · Puzzle · Adventure

Return to Mysterious Island
Shared: Adventure · Point & Click · Casual

Iris.Fall
Shared: Adventure · Casual · Puzzle

Broken Age
Shared: Adventure · Point & Click · Casual

Rise of the Tomb Raider™
Shared: Adventure · Female Protagonist · Singleplayer

The Mr. Rabbit Magic Show
Shared: Adventure · Point & Click · Puzzle

Syberia 3
Shared: Adventure · Point & Click · Puzzle

Boxes: Lost Fragments
Shared: Point & Click · Adventure · Puzzle

Call of the Sea
Shared: Adventure · Puzzle · Female Protagonist

Chants of Sennaar
Shared: Adventure · Puzzle · Point & Click

The Escaper
Shared: Adventure · Point & Click · Puzzle

Underground Blossom
Shared: Adventure · Point & Click · Puzzle

Tomb Raider Game of the Year
Shared: Adventure · Female Protagonist · Singleplayer

Portal
Shared: Puzzle · First-Person · Singleplayer

Slime Rancher
Shared: Adventure · Singleplayer · First-Person

Servant of the Lake
Shared: Adventure · Point & Click · Puzzle