Games like Railway Empire 2
Games like Railway Empire 2 include Transport Fever 2, Cities: Skylines, Cities: Skylines II, Railway Empire, and Manor Lords. We matched them by the tags players give Railway Empire 2 on Steam (Simulation, Strategy, Trains, Management, and Transportation): closest matches first, and among equally close ones the better-known games.

Transport Fever 2
Shared: Simulation · Strategy · Management

Cities: Skylines
Shared: Simulation · Strategy · Management

Cities: Skylines II
Shared: Simulation · Management · Sandbox

Railway Empire
Shared: Simulation · Strategy · Trains

Manor Lords
Shared: Strategy · Simulation · Management

Anno 1800
Shared: Strategy · Simulation · Economy

Jurassic World Evolution
Shared: Simulation · Strategy · Management

Anno 117: Pax Romana
Shared: Strategy · Simulation · Sandbox

Prison Architect
Shared: Simulation · Strategy · Sandbox

Jurassic World Evolution 2
Shared: Simulation · Management · Strategy

Transport Fever 3
Shared: Simulation · Management · Transportation

Against the Storm
Shared: Simulation · Strategy · Management

Kingdoms and Castles
Shared: Simulation · Management · Strategy

Workers & Resources: Soviet Republic
Shared: Strategy · Simulation · Management

Planet Zoo
Shared: Simulation · Management · Sandbox

Foundation
Shared: Simulation · Strategy · Management

Planet Coaster
Shared: Simulation · Management · Strategy

Tropico 6
Shared: Strategy · Simulation · Management

Empires of the Undergrowth
Shared: Simulation · Strategy · Management

News Tower
Shared: Simulation · Strategy · Management

Tropico 5
Shared: Strategy · Simulation · Sandbox

Train Fever
Shared: Simulation · Trains · Strategy

Transport Fever
Shared: Sandbox · Management · Trains

Factorio
Shared: Strategy · Sandbox · Resource Management