Games like Quest: Escape Room 2
Games like Quest: Escape Room 2 include Machinarium, There Is No Game: Wrong Dimension, Stray, Chants of Sennaar, and Monument Valley. We matched them by the tags players give Quest: Escape Room 2 on Steam (Adventure, Puzzle, Casual, Exploration, and Point & Click): closest matches first, and among equally close ones the better-known games.

Machinarium
Shared: Puzzle · Point & Click · Adventure

There Is No Game: Wrong Dimension
Shared: Puzzle · Adventure · Point & Click

Stray
Shared: Adventure · Exploration · Puzzle

Chants of Sennaar
Shared: Adventure · Puzzle · Point & Click

Monument Valley
Shared: Puzzle · Adventure · Casual

Storyteller
Shared: Puzzle · Adventure · Point & Click

Rise of the Tomb Raider™
Shared: Adventure · Exploration · Puzzle

Strange Jigsaws
Shared: Adventure · Puzzle · Casual

Gorogoa
Shared: Puzzle · Casual · Point & Click

The Room 4: Old Sins
Shared: Puzzle · Adventure · Point & Click

Terraria
Shared: Adventure · 2D · Survival

DAVE THE DIVER
Shared: Adventure · Casual · Exploration

Unboxing the Cryptic Killer
Shared: Puzzle · Adventure · Point & Click

The Silent Age
Shared: Adventure · Point & Click · Puzzle

The Room
Shared: Puzzle · Adventure · Point & Click

Return to Monkey Island
Shared: Adventure · Puzzle · Point & Click

Deponia
Shared: Adventure · Puzzle · Point & Click

FEZ
Shared: Puzzle · Exploration · Adventure

Scribblenauts Unlimited
Shared: Puzzle · Adventure · Casual

Turnip Boy Commits Tax Evasion
Shared: Puzzle · Exploration · Top-Down

Big Walk
Shared: Puzzle · Adventure · Exploration

Outer Wilds
Shared: Exploration · Adventure · Puzzle

Morphopolis
Shared: Puzzle · Adventure · Casual

Neighbours back From Hell
Shared: Puzzle · Point & Click · Adventure