Games like Purrfect Alchemy
Games like Purrfect Alchemy include Bloons TD 6, Vampire Survivors, Plants vs. Zombies GOTY Edition, Bloons TD 5, and Kingdom Rush - Tower Defense. We matched them by the tags players give Purrfect Alchemy on Steam (Action, Casual, Local Co-Op, Family Friendly, and Cute): closest matches first, and among equally close ones the better-known games.

Bloons TD 6
Shared: Tower Defense · Casual · Family Friendly

Vampire Survivors
Shared: Action Roguelike · Casual · Action

Plants vs. Zombies GOTY Edition
Shared: Casual · Tower Defense · Strategy

Bloons TD 5
Shared: Action · Family Friendly · Casual

Kingdom Rush - Tower Defense
Shared: Casual · Action · Tower Defense

Overcooked! 2
Shared: Local Co-Op · Casual · Action

Juicy Realm
Shared: Action · Casual · Action Roguelike

Risk of Rain Returns
Shared: Action Roguelike · Local Co-Op · Action

Pikuniku
Shared: Casual · Cute · Action

Rabbit and Steel
Shared: Cute · Action Roguelike · Action

Wizard of Legend
Shared: Local Co-Op · Action · Action Roguelike

Enter the Gungeon
Shared: Action Roguelike · Local Co-Op · Roguelike

Party Animals
Shared: Casual · Cute · Action

Skul: The Hero Slayer
Shared: Action · Action Roguelike · Roguelike

Octogeddon
Shared: Action · Casual · Action Roguelike

Tangy TD
Shared: Action · Tower Defense · Strategy

The Binding of Isaac: Rebirth
Shared: Action Roguelike · Roguelike · Local Co-Op

Risk of Rain (2013)
Shared: Action · Action Roguelike · Roguelike

Jianghu Survivor
Shared: Action · Casual · Action Roguelike

Kingdom Rush Frontiers - Tower Defense
Shared: Tower Defense · Casual · Strategy

Wedding Witch
Shared: Action · Casual · Action Roguelike

Hades
Shared: Action · Action Roguelike · Roguelike

Cluckmech Oasis
Shared: Action · Cute · Tower Defense

Kingdom Rush Origins - Tower Defense
Shared: Casual · Tower Defense · Strategy