Games like Prune
Games like Prune include Mini Motorways, Mountain, Unpacking, inbento, and Potion Craft: Alchemist Simulator. We matched them by the tags players give Prune on Steam (Simulation, Relaxing, Casual, Nature, and Emotional): closest matches first, and among equally close ones the better-known games.

Mini Motorways
Shared: Simulation · Casual · Relaxing

Mountain
Shared: Simulation · Casual · Relaxing

Unpacking
Shared: Relaxing · Casual · Simulation

inbento
Shared: Casual · Puzzle · Relaxing

Potion Craft: Alchemist Simulator
Shared: Relaxing · Simulation · Singleplayer

Hook
Shared: Casual · Relaxing · Puzzle

Zup! S
Shared: Casual · Puzzle · Relaxing

Mini Metro
Shared: Simulation · Puzzle · Casual

Sticky Business
Shared: Relaxing · Simulation · Casual

Terra Nil
Shared: Relaxing · Nature · Puzzle

Librarian: Tidy Up the Arcane Library!
Shared: Relaxing · Casual · Simulation

Reus
Shared: Simulation · Casual · Indie

Ballads of Hongye: REBORN
Shared: Simulation · Casual · Relaxing

Samorost 1
Shared: Casual · Relaxing · Puzzle

Equilinox
Shared: Simulation · Casual · Relaxing

A Little to the Left
Shared: Relaxing · Puzzle · Casual

Leaf it Alone
Shared: Relaxing · Simulation · Casual

Pixel Puzzles: Japan
Shared: Casual · Simulation · Puzzle

House Flipper
Shared: Simulation · Relaxing · Casual

Townscaper
Shared: Relaxing · Casual · Simulation

Dorfromantik
Shared: Relaxing · Casual · Puzzle

Spilled!
Shared: Relaxing · Casual · Simulation

klocki
Shared: Relaxing · Casual · Puzzle

Papers, Please
Shared: Simulation · Indie · Puzzle