Games like Prime World: Defenders
Games like Prime World: Defenders include Plants vs. Zombies GOTY Edition, Kingdom Rush - Tower Defense, Bloons TD 6, GemCraft - Chasing Shadows, and Rock 'N' Roll Defense. We matched them by the tags players give Prime World: Defenders on Steam (Tower Defense, Strategy, Indie, Card Game, and Singleplayer): closest matches first, and among equally close ones the better-known games.

Plants vs. Zombies GOTY Edition
Shared: Tower Defense · Strategy · Singleplayer

Kingdom Rush - Tower Defense
Shared: Tower Defense · Strategy · Singleplayer

Bloons TD 6
Shared: Tower Defense · Strategy · Singleplayer

GemCraft - Chasing Shadows
Shared: Tower Defense · Strategy · Indie

Rock 'N' Roll Defense
Shared: Tower Defense · Strategy · Casual

Kingdom Rush Origins - Tower Defense
Shared: Tower Defense · Strategy · Singleplayer

Kingdom Rush Frontiers - Tower Defense
Shared: Tower Defense · Strategy · Singleplayer

Orcs Must Die!
Shared: Tower Defense · Strategy · Indie

Dungeon Defenders
Shared: Tower Defense · Strategy · Singleplayer

Orcs Must Die! 2
Shared: Tower Defense · Strategy · Indie

Idle Champions of the Forgotten Realms
Shared: Strategy · Fantasy · Singleplayer

Overdungeon
Shared: Strategy · Indie · Casual

Kingdom Rush 5: Alliance TD
Shared: Tower Defense · Strategy · Singleplayer

Balatro
Shared: Card Game · Strategy · Singleplayer

Sultan's Game
Shared: Strategy · Singleplayer · Card Game

Plague Inc: Evolved
Shared: Strategy · Indie · Singleplayer

Bardbarian
Shared: Tower Defense · Indie · Strategy

GWENT: The Witcher Card Game
Shared: Strategy · Card Game · RPG

Warstone TD
Shared: Tower Defense · Strategy · Indie

Slay the Spire
Shared: Card Game · Strategy · Singleplayer

Town of Salem
Shared: Strategy · Indie · Casual

Reigns
Shared: Indie · Card Game · Singleplayer

Caster
Shared: Indie · Strategy · Casual

Home Behind
Shared: Indie · Strategy · RPG