Games like Prime Protocol
Games like Prime Protocol include Rogue Legacy 2, Celeste, Super Meat Boy, Skul: The Hero Slayer, and Pogostuck: Rage With Your Friends. We matched them by the tags players give Prime Protocol on Steam (Platformer, Roguelite, Precision Platformer, Procedural Generation, and Action): closest matches first, and among equally close ones the better-known games.

Rogue Legacy 2
Shared: Platformer · Roguelite · Action

Celeste
Shared: Precision Platformer · Platformer · Indie

Super Meat Boy
Shared: Platformer · Precision Platformer · Indie

Skul: The Hero Slayer
Shared: Action · Indie · Roguelite

Pogostuck: Rage With Your Friends
Shared: Precision Platformer · Platformer · Action

Downwell
Shared: Precision Platformer · Platformer · Indie

Spelunky 2
Shared: Platformer · Perma Death · Procedural Generation

Hollow Knight
Shared: Platformer · Indie · Difficult

Spelunky
Shared: Platformer · Indie · Procedural Generation

Cargo Commander
Shared: Roguelite · Procedural Generation · Platformer

Risk of Rain (2013)
Shared: Platformer · Action · Indie

Geometry Dash
Shared: Precision Platformer · Platformer · Difficult

Hades
Shared: Roguelite · Action · Indie

Jump King
Shared: Precision Platformer · Platformer · Indie

FTL: Faster Than Light
Shared: Indie · Perma Death · Sci-fi

GoNNER
Shared: Roguelite · Platformer · Indie

Caveblazers
Shared: Platformer · Roguelite · Procedural Generation

VVVVVV
Shared: Platformer · Precision Platformer · Indie

Rogue Legacy
Shared: Platformer · Action · Indie

The End Is Nigh
Shared: Platformer · Precision Platformer · Indie

Nine Sols
Shared: Platformer · Action · Indie

The Binding of Isaac
Shared: Procedural Generation · Indie · Action

Hollow Knight: Silksong
Shared: Platformer · Indie · Difficult

ScourgeBringer
Shared: Roguelite · Action · Indie