Games like Portal Guardians
Games like Portal Guardians include Magicka, Orcs Must Die! 2, Bloons TD 6, Orcs Must Die! 3, and Magicka 2. We matched them by the tags players give Portal Guardians on Steam (Tower Defense, Action, Idler, Strategy, and Magic): closest matches first, and among equally close ones the better-known games.

Magicka
Shared: Co-op · Action · Comedy

Orcs Must Die! 2
Shared: Tower Defense · Co-op · Action

Bloons TD 6
Shared: Tower Defense · Strategy · Co-op

Orcs Must Die! 3
Shared: Tower Defense · Co-op · Strategy

Magicka 2
Shared: Co-op · Magic · Action

Orcs Must Die!
Shared: Tower Defense · Action · Strategy

Monster Hunter: World
Shared: Co-op · Action · Multiplayer

Bloons TD 5
Shared: Tower Defense · Co-op · Strategy

Borderlands 2
Shared: Action · Co-op · Multiplayer

PEAK
Shared: Co-op · Multiplayer · Comedy

Dungeon Defenders
Shared: Tower Defense · Strategy · Multiplayer

Orcs Must Die! Deathtrap
Shared: Tower Defense · Co-op · Action

Human Fall Flat
Shared: Co-op · Funny · Action

Kingdom Rush - Tower Defense
Shared: Tower Defense · Strategy · Action

Sanctum 2
Shared: Tower Defense · Co-op · Action

Warhammer 40,000: Space Marine 2
Shared: Co-op · Action · Multiplayer

Gang Beasts
Shared: Co-op · Action · Funny

Who's Your Daddy?!
Shared: Funny · Co-op · Strategy

Deathtrap
Shared: Tower Defense · Action · Co-op

Dungeon Defenders: Awakened
Shared: Co-op · Tower Defense · Strategy

Rock of Ages 2: Bigger & Boulder™
Shared: Action · Strategy · Tower Defense

Borderlands: The Pre-Sequel
Shared: Co-op · Action · Comedy

Monster Hunter Wilds
Shared: Action · Co-op · Multiplayer

RV There Yet?
Shared: Co-op · Funny · Multiplayer