Games like Plague: London 1665
Games like Plague: London 1665 include Undertale, The Witcher 3: Wild Hunt — Remastered, Assassin's Creed® Odyssey, OneShot, and OMORI. We matched them by the tags players give Plague: London 1665 on Steam (RPG, Action-Adventure, Simulation, 2D, and Historical): closest matches first, and among equally close ones the better-known games.

Undertale
Shared: RPG · Choices Matter · Story Rich

The Witcher 3: Wild Hunt — Remastered
Shared: RPG · Adventure · Story Rich

Assassin's Creed® Odyssey
Shared: Action-Adventure · RPG · Historical

OneShot
Shared: Indie · Story Rich · Pixel Graphics

OMORI
Shared: RPG · Indie · Story Rich

Papers, Please
Shared: Simulation · Indie · Multiple Endings

Assassin's Creed® Origins
Shared: Action-Adventure · RPG · Historical

Back to the Dawn
Shared: RPG · Choices Matter · Adventure

The Test
Shared: Simulation · Multiple Endings · Story Rich

Graveyard Keeper
Shared: RPG · Simulation · Pixel Graphics

Kingdom Come: Deliverance II
Shared: RPG · Adventure · Historical

Keep Driving
Shared: RPG · Adventure · Pixel Graphics

Kingdom Come: Deliverance
Shared: RPG · Historical · Adventure

Yes, Your Grace
Shared: RPG · Choices Matter · Indie

鬼谷八荒 Tale of Immortal
Shared: Simulation · RPG · Adventure

Finding Paradise
Shared: RPG · 2D · Adventure

Emily is Away Too
Shared: Simulation · Choices Matter · Indie

Heartbound
Shared: RPG · Adventure · 2D

Baldur's Gate 3
Shared: RPG · Choices Matter · Adventure

To the Moon
Shared: Adventure · RPG · Indie

Impostor Factory
Shared: RPG · 2D · Adventure

SANABI
Shared: Adventure · 2D · Action-Adventure

Tales of the Black Forest
Shared: RPG · Adventure · Indie

Martial Law
Shared: Choices Matter · Adventure · 2D