Games like Pixel Starships 2
Games like Pixel Starships 2 include Dyson Sphere Program, FTL: Faster Than Light, Elite Dangerous, Stellaris, and X4: Foundations. We matched them by the tags players give Pixel Starships 2 on Steam (Space, Strategy, Massively Multiplayer, Roguelike, and Automation): closest matches first, and among equally close ones the better-known games.

Dyson Sphere Program
Shared: Space · Automation · Base Building

FTL: Faster Than Light
Shared: Space · Strategy · Roguelike

Elite Dangerous
Shared: Space · Massively Multiplayer · Sci-fi

Stellaris
Shared: Space · Strategy · Sci-fi

X4: Foundations
Shared: Space · Strategy · Sci-fi

STAR WARS™ Empire at War - Gold Pack
Shared: Strategy · Space · Sci-fi

Space Haven
Shared: Strategy · Space · Base Building

The Crust
Shared: Space · Automation · Base Building

Sins of a Solar Empire II
Shared: Space · Strategy · Sci-fi

Homeworld 3
Shared: Space · Strategy · Sci-fi

SpaceCraft
Shared: Space · Massively Multiplayer · Sci-fi

Planetary Annihilation: TITANS
Shared: Strategy · RTS · Base Building

Starpoint Gemini Warlords
Shared: Space · Strategy · Sci-fi

Battlefleet Gothic: Armada 2
Shared: Space · Strategy · Sci-fi

ENDLESS Space™ 2
Shared: Space · Strategy · Sci-fi

Homeworld Remastered Collection
Shared: Space · Strategy · Sci-fi

Star Trek: Voyager - Across the Unknown
Shared: Strategy · Roguelike · Space

Sid Meier's Civilization®: Beyond Earth™
Shared: Strategy · Space · Sci-fi

Total War: WARHAMMER
Shared: Strategy · RTS · Simulation

Hardspace: Shipbreaker
Shared: Space · Sci-fi · Strategy

Battlefleet Gothic: Armada (Classic)
Shared: Space · Strategy · Sci-fi

The King is Watching
Shared: Roguelike · Strategy · Base Building

Mindustry
Shared: Automation · Strategy · Base Building

EVE Online
Shared: Space · Space Sim · Massively Multiplayer