Games like Pixel Descent
Games like Pixel Descent include Vampire Survivors, Enter the Gungeon, The Binding of Isaac: Rebirth, Death Must Die, and Megabonk. We matched them by the tags players give Pixel Descent on Steam (Action Roguelike, Indie, Bullet Hell, Pixel Graphics, and Shoot 'Em Up): closest matches first, and among equally close ones the better-known games.

Vampire Survivors
Shared: Action Roguelike · Bullet Hell · Pixel Graphics

Enter the Gungeon
Shared: Action Roguelike · Bullet Hell · Pixel Graphics

The Binding of Isaac: Rebirth
Shared: Action Roguelike · Indie · Pixel Graphics

Death Must Die
Shared: Action Roguelike · Bullet Hell · Pixel Graphics

Megabonk
Shared: Action Roguelike · Indie · Bullet Hell

Boneraiser Minions
Shared: Action Roguelike · Bullet Hell · Pixel Graphics

Halls of Torment
Shared: Action Roguelike · Bullet Hell · Pixel Graphics

Skul: The Hero Slayer
Shared: Indie · Action Roguelike · Pixel Graphics

20 Minutes Till Dawn
Shared: Action Roguelike · Bullet Hell · Shoot 'Em Up

BALL x PIT
Shared: Bullet Hell · Action Roguelike · Action

Dungreed
Shared: Action Roguelike · Pixel Graphics · Indie

Star of Providence
Shared: Action Roguelike · Bullet Hell · Indie

UnderMine
Shared: Action Roguelike · Pixel Graphics · Indie

Planes, Bullets and Vodka
Shared: Casual · Bullet Hell · Shoot 'Em Up

LUFTRAUSERS
Shared: Indie · Bullet Hell · Pixel Graphics

Hades
Shared: Action Roguelike · Indie · Action

Rogue Legacy
Shared: Indie · Action Roguelike · 2D

Realm of the Mad God Exalt
Shared: Pixel Graphics · Bullet Hell · Action Roguelike

Nuclear Throne
Shared: Action Roguelike · Indie · Pixel Graphics

Hero Siege
Shared: Action Roguelike · Pixel Graphics · Indie

Nova Drift
Shared: Bullet Hell · Action Roguelike · Shoot 'Em Up

Desktop Survivors 98
Shared: Action Roguelike · Bullet Hell · Casual

I Am Legion: Stand Survivors
Shared: Action Roguelike · Bullet Hell · Indie

Bit Blaster XL
Shared: Bullet Hell · Shoot 'Em Up · 2D