Games like Pilot Brothers 2
Games like Pilot Brothers 2 include The Room, There Is No Game: Wrong Dimension, Syberia, Chants of Sennaar, and The Room 4: Old Sins. We matched them by the tags players give Pilot Brothers 2 on Steam (Adventure, Casual, Point & Click, Singleplayer, and Puzzle): closest matches first, and among equally close ones the better-known games.

The Room
Shared: Point & Click · Puzzle · Adventure

There Is No Game: Wrong Dimension
Shared: Adventure · Point & Click · Puzzle

Syberia
Shared: Adventure · Point & Click · Casual

Chants of Sennaar
Shared: Adventure · Puzzle · Singleplayer

The Room 4: Old Sins
Shared: Adventure · Point & Click · Puzzle

Monument Valley
Shared: Adventure · Puzzle · Casual

Neighbours from Hell Compilation
Shared: Casual · Point & Click · Classic

Gorogoa
Shared: Puzzle · Singleplayer · Casual

Deponia
Shared: Adventure · Point & Click · Singleplayer

Grim Fandango Remastered
Shared: Adventure · Point & Click · Classic

Broken Age
Shared: Adventure · Point & Click · Singleplayer

Storyteller
Shared: Point & Click · Adventure · Puzzle

Return to Monkey Island
Shared: Adventure · Point & Click · Puzzle

My Brother Rabbit
Shared: Adventure · Point & Click · Puzzle

Neighbours back From Hell
Shared: Point & Click · Puzzle · Adventure

The Secret of Monkey Island: Special Edition
Shared: Adventure · Point & Click · Classic

The Room Two
Shared: Point & Click · Puzzle · Adventure

The Room Three
Shared: Adventure · Puzzle · Point & Click

Plants vs. Zombies GOTY Edition
Shared: Casual · Singleplayer · Classic

Morphopolis
Shared: Puzzle · Point & Click · Casual

Myst: Masterpiece Edition
Shared: Adventure · Casual · Point & Click

Boxes: Lost Fragments
Shared: Adventure · Point & Click · Puzzle

Deponia: The Complete Journey
Shared: Adventure · Point & Click · Singleplayer

Scribblenauts Unlimited
Shared: Casual · Adventure · Puzzle