Games like PHYSARUM: Slime Mold Simulator
Games like PHYSARUM: Slime Mold Simulator include Universe Sandbox, Kerbal Space Program, Universe Sandbox, SPORE™, and Thrive. We matched them by the tags players give PHYSARUM: Slime Mold Simulator on Steam (Simulation, Sandbox, Casual, Science, and Education): closest matches first, and among equally close ones the better-known games.

Universe Sandbox
Shared: Simulation · Sandbox · Science

Kerbal Space Program
Shared: Simulation · Sandbox · Science

Universe Sandbox
Shared: Simulation · Sandbox · Science

SPORE™
Shared: Sandbox · Simulation · God Game

Thrive
Shared: Simulation · Sandbox · Science

House Flipper
Shared: Simulation · Sandbox · Casual

The Sapling
Shared: Sandbox · Science · Simulation

Reus
Shared: Simulation · Sandbox · God Game

Garry's Mod
Shared: Sandbox · Casual · Simulation

Game Dev Tycoon
Shared: Simulation · Casual · Indie

PC Building Simulator
Shared: Simulation · Education · Sandbox

Mountain
Shared: Simulation · Casual · Indie

SpaceEngine
Shared: Casual · Sandbox · Science

Equilinox
Shared: Simulation · Casual · Sandbox

People Playground
Shared: Sandbox · Simulation · 2D

WorldBox - God Simulator
Shared: Sandbox · Simulation · God Game

Sand:box
Shared: Simulation · Sandbox · God Game

Everything
Shared: Simulation · Casual · Sandbox

鬼谷八荒 Tale of Immortal
Shared: Simulation · Sandbox · Singleplayer

Planetary Life
Shared: Sandbox · Simulation · Science

while True: learn()
Shared: Simulation · Education · Science

Sandboxels
Shared: Sandbox · Science · Education

Goat Simulator
Shared: Simulation · Sandbox · Casual

Spaceflight Simulator
Shared: Sandbox · Simulation · Science