Games like Panic Room: House of secrets
Games like Panic Room: House of secrets include Poppy Playtime, The Room, The Room Two, We Were Here, and The Room Three. We matched them by the tags players give Panic Room: House of secrets on Steam (Free to Play, Hidden Object, Adventure, Casual, and Puzzle): closest matches first, and among equally close ones the better-known games.

Poppy Playtime
Shared: Free to Play · Puzzle · Horror

The Room
Shared: Puzzle · Mystery · Adventure

The Room Two
Shared: Puzzle · Hidden Object · Mystery

We Were Here
Shared: Free to Play · Puzzle · Adventure

The Room Three
Shared: Adventure · Puzzle · Mystery

Firework
Shared: Puzzle · Mystery · Horror

Samsara Room
Shared: Free to Play · Adventure · Puzzle

The Room 4: Old Sins
Shared: Puzzle · Adventure · Mystery

Sally Face - Episode One
Shared: Adventure · Puzzle · Psychological Horror

Rusty Lake Paradise
Shared: Puzzle · Adventure · Psychological Horror

The Incident at Galley House
Shared: Puzzle · Mystery · Adventure

Varenje
Shared: Free to Play · Adventure · Hidden Object

Danganronpa 2: Goodbye Despair
Shared: Detective · Mystery · Adventure

The House of Da Vinci
Shared: Hidden Object · Puzzle · Mystery

Cube Escape Collection
Shared: Puzzle · Mystery · Psychological Horror

The White Door
Shared: Adventure · Puzzle · Detective

Return of the Obra Dinn
Shared: Puzzle · Mystery · Detective

Little Nightmares II
Shared: Adventure · Puzzle · Horror

The Rewinder
Shared: Adventure · Mystery · Puzzle

Enigmatis 2: The Mists of Ravenwood
Shared: Hidden Object · Adventure · Casual

Enigmatis: The Ghosts of Maple Creek
Shared: Hidden Object · Adventure · Casual

Murdered: Soul Suspect
Shared: Adventure · Detective · Mystery

True Fear: Forsaken Souls Part 2
Shared: Adventure · Hidden Object · Casual

Sherlock Holmes: The Devil's Daughter
Shared: Adventure · Detective · Puzzle