Games like Packed Lair
Games like Packed Lair include Backpack Battles, The King is Watching, 9 Kings, Knightica, and Kingdom Rush - Tower Defense. We matched them by the tags players give Packed Lair on Steam (Auto Battler, Base Building, Strategy, Inventory Management, and Deckbuilding): closest matches first, and among equally close ones the better-known games.

Backpack Battles
Shared: Auto Battler · Strategy · Inventory Management

The King is Watching
Shared: Base Building · Roguelike · Strategy

9 Kings
Shared: Auto Battler · Strategy · Roguelike

Knightica
Shared: Auto Battler · Deckbuilding · Roguelike

Kingdom Rush - Tower Defense
Shared: Strategy · Tactical · 2D

Slay the Spire 2
Shared: Roguelike · Strategy · Deckbuilding

Balatro
Shared: Roguelike · Deckbuilding · Strategy

RimWorld
Shared: Base Building · Strategy · Management

Super Fantasy Kingdom
Shared: Strategy · Auto Battler · Roguelike

Emberward
Shared: Strategy · Base Building · Deckbuilding

Loop Hero
Shared: Roguelike · Tactical · Deckbuilding

Slay the Spire
Shared: Deckbuilding · Roguelike · Strategy

Tower Dominion
Shared: Base Building · Strategy · Roguelike

Gladiator Guild Manager
Shared: Auto Battler · Strategy · Management

Backpack Hero
Shared: Inventory Management · Deckbuilding · Strategy

Poly TD
Shared: Auto Battler · Strategy · Tactical

Oxygen Not Included
Shared: Base Building · Management · Strategy

He is Coming
Shared: Auto Battler · Strategy · Roguelike

Age of Empires II (Retired)
Shared: Strategy · Base Building · Tactical

Kingdom Two Crowns
Shared: Base Building · Strategy · Tower Defense

The Bazaar
Shared: Auto Battler · Strategy · Deckbuilding

Kingdom Rush 6: Genesis TD
Shared: Strategy · Base Building · 2D

Just King
Shared: Auto Battler · Strategy · Roguelike

Kingdom Rush 5: Alliance TD
Shared: Strategy · 2D · Singleplayer